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Apolipoprotein E gene polymorphism in the Mongolian population.
Folia Biol (Praha) 2007; 53(4):138-42FB

Abstract

Apolipoprotein E plays a key role in the regulation of lipid metabolism. ApoE function is determined by the presence of three common alleles (epsilon2, epsilon3, epsilon4). The apo epsilon3 allele is the most prevalent, apo epsilon2 is associated with dysbetalipoproteinaemia, and apo epsilon4 is frequently associated with an increased risk for cardiovascular and Alzheimer's diseases. Mongolian population has a high rate of cardiovascular mortality and morbidity and there might be genetic susceptibility of the population to cardiovascular disease. The aim of our study was to establish the frequency of apoE genotypes in 744 Mongolian subjects and to compare the results with findings from other Asian populations. The apo E sequence was amplified using polymerase chain reaction and apo E genotyping was performed by restriction enzyme cleavage with CfoI. The relative apoE allele frequencies were epsilon2 = 3.7%, epsilon3 = 80.8%, and epsilon4 = 15.5%, the genotype frequencies were epsilon2/epsilon2 = 0% (N = 0), epsilon2/epsilon3 = 5.7% (N = 42), epsilon2/epsilon4 = 1.7% (N = 13), epsilon3/epsilon3 = 65.3% (N = 486), epsilon3/epsilon4 = 25.4% (N = 189), epsilon4/epsilon4 = 1.9% (N = 14); the occurrence of the risk epsilon4 allele in Mongolia is among the highest in Asia. The high frequency of the apo epsilon4 allele may increase the susceptibility of Mongolian population to cardiovascular diseases.

Authors+Show Affiliations

Third Medical Department, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic. svobodoh@centrum.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17706019

Citation

Svobodová, H, et al. "Apolipoprotein E Gene Polymorphism in the Mongolian Population." Folia Biologica, vol. 53, no. 4, 2007, pp. 138-42.
Svobodová H, Kucera F, Stulc T, et al. Apolipoprotein E gene polymorphism in the Mongolian population. Folia Biol (Praha). 2007;53(4):138-42.
Svobodová, H., Kucera, F., Stulc, T., Vrablík, M., Amartuvshin, B., Altannavch, T. s., & Ceska, R. (2007). Apolipoprotein E gene polymorphism in the Mongolian population. Folia Biologica, 53(4), pp. 138-42.
Svobodová H, et al. Apolipoprotein E Gene Polymorphism in the Mongolian Population. Folia Biol (Praha). 2007;53(4):138-42. PubMed PMID: 17706019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene polymorphism in the Mongolian population. AU - Svobodová,H, AU - Kucera,F, AU - Stulc,T, AU - Vrablík,M, AU - Amartuvshin,B, AU - Altannavch,Ts, AU - Ceska,R, PY - 2007/8/21/pubmed PY - 2007/9/13/medline PY - 2007/8/21/entrez SP - 138 EP - 42 JF - Folia biologica JO - Folia Biol. (Praha) VL - 53 IS - 4 N2 - Apolipoprotein E plays a key role in the regulation of lipid metabolism. ApoE function is determined by the presence of three common alleles (epsilon2, epsilon3, epsilon4). The apo epsilon3 allele is the most prevalent, apo epsilon2 is associated with dysbetalipoproteinaemia, and apo epsilon4 is frequently associated with an increased risk for cardiovascular and Alzheimer's diseases. Mongolian population has a high rate of cardiovascular mortality and morbidity and there might be genetic susceptibility of the population to cardiovascular disease. The aim of our study was to establish the frequency of apoE genotypes in 744 Mongolian subjects and to compare the results with findings from other Asian populations. The apo E sequence was amplified using polymerase chain reaction and apo E genotyping was performed by restriction enzyme cleavage with CfoI. The relative apoE allele frequencies were epsilon2 = 3.7%, epsilon3 = 80.8%, and epsilon4 = 15.5%, the genotype frequencies were epsilon2/epsilon2 = 0% (N = 0), epsilon2/epsilon3 = 5.7% (N = 42), epsilon2/epsilon4 = 1.7% (N = 13), epsilon3/epsilon3 = 65.3% (N = 486), epsilon3/epsilon4 = 25.4% (N = 189), epsilon4/epsilon4 = 1.9% (N = 14); the occurrence of the risk epsilon4 allele in Mongolia is among the highest in Asia. The high frequency of the apo epsilon4 allele may increase the susceptibility of Mongolian population to cardiovascular diseases. SN - 0015-5500 UR - https://www.unboundmedicine.com/medline/citation/17706019/Apolipoprotein_E_gene_polymorphism_in_the_Mongolian_population_ L2 - https://fb.cuni.cz/volume-53-2007-no-4#articFB2007A0020 DB - PRIME DP - Unbound Medicine ER -