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In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension.
Bioresour Technol. 2008 May; 99(8):2981-8.BT

Abstract

National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association recommend eggplant-based diet as a choice for management of type 2 diabetes. The rationale for this suggestion is the high fiber and low soluble carbohydrate content of eggplant. We propose that a more physiologically relevant explanation lies in the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis. Results from this study indicate that phenolic-enriched extracts of eggplant with moderate free radical scavenging-linked antioxidant activity had high alpha-glucosidase inhibitory activity and in specific cases moderate to high angiotensin I-converting enzyme (ACE) inhibitory activity. Inhibition of these enzymes provide a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively. This phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress. These results provide strong rationale for further animal and clinical studies.

Authors+Show Affiliations

Laboratory of Food Biotechnology, Department of Food Science, Chenoweth Building, University of Massachusetts, Amherst, MA 01003, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17706416

Citation

Kwon, Y-I, et al. "In Vitro Studies of Eggplant (Solanum Melongena) Phenolics as Inhibitors of Key Enzymes Relevant for Type 2 Diabetes and Hypertension." Bioresource Technology, vol. 99, no. 8, 2008, pp. 2981-8.
Kwon YI, Apostolidis E, Shetty K. In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour Technol. 2008;99(8):2981-8.
Kwon, Y. I., Apostolidis, E., & Shetty, K. (2008). In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresource Technology, 99(8), 2981-8.
Kwon YI, Apostolidis E, Shetty K. In Vitro Studies of Eggplant (Solanum Melongena) Phenolics as Inhibitors of Key Enzymes Relevant for Type 2 Diabetes and Hypertension. Bioresour Technol. 2008;99(8):2981-8. PubMed PMID: 17706416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. AU - Kwon,Y-I, AU - Apostolidis,E, AU - Shetty,K, Y1 - 2007/08/13/ PY - 2007/04/06/received PY - 2007/06/05/revised PY - 2007/06/05/accepted PY - 2007/8/21/pubmed PY - 2008/6/20/medline PY - 2007/8/21/entrez SP - 2981 EP - 8 JF - Bioresource technology JO - Bioresour Technol VL - 99 IS - 8 N2 - National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association recommend eggplant-based diet as a choice for management of type 2 diabetes. The rationale for this suggestion is the high fiber and low soluble carbohydrate content of eggplant. We propose that a more physiologically relevant explanation lies in the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis. Results from this study indicate that phenolic-enriched extracts of eggplant with moderate free radical scavenging-linked antioxidant activity had high alpha-glucosidase inhibitory activity and in specific cases moderate to high angiotensin I-converting enzyme (ACE) inhibitory activity. Inhibition of these enzymes provide a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively. This phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress. These results provide strong rationale for further animal and clinical studies. SN - 0960-8524 UR - https://www.unboundmedicine.com/medline/citation/17706416/In_vitro_studies_of_eggplant__Solanum_melongena__phenolics_as_inhibitors_of_key_enzymes_relevant_for_type_2_diabetes_and_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-8524(07)00534-2 DB - PRIME DP - Unbound Medicine ER -