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Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa.
Biol Psychiatry. 2008 Jan 15; 63(2):245-7.BP

Abstract

BACKGROUND

Obestatin is a recently identified peptide encoded by the same ghrelin gene. It has been reported that obestatin has anorexigenic and antigastroprokinetic activities as opposed to ghrelin. We investigated simultaneously obestatin, acyl ghrelin, and des-acyl ghrelin in the restricting type of anorexia nervosa (AN-R) patients.

METHODS

Three hormonal responses to the oral glucose tolerance test (OGTT) were measured in 10 AN-R patients and 10 healthy women.

RESULTS

Plasma obestatin, acyl ghrelin, and des-acyl ghrelin levels were significantly higher in AN-R patients than in control subjects throughout the OGTT. All of the three hormones decreased after the OGTT in both groups.

CONCLUSIONS

We found that AN-R patients exhibited increased plasma levels of obestatin, acyl ghrelin, and des-acyl ghrelin throughout the OGTT compared with control subjects. The hormonal differences between groups are statistically most significant in obestatin, suggesting obestatin may serve as a marker reflecting both acute and chronic changes of the nutritional state in AN-R patients.

Authors+Show Affiliations

Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City, Japan. toshiro@m2.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17706613

Citation

Harada, Toshiro, et al. "Obestatin, Acyl Ghrelin, and Des-acyl Ghrelin Responses to an Oral Glucose Tolerance Test in the Restricting Type of Anorexia Nervosa." Biological Psychiatry, vol. 63, no. 2, 2008, pp. 245-7.
Harada T, Nakahara T, Yasuhara D, et al. Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa. Biol Psychiatry. 2008;63(2):245-7.
Harada, T., Nakahara, T., Yasuhara, D., Kojima, S., Sagiyama, K., Amitani, H., Laviano, A., Naruo, T., & Inui, A. (2008). Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa. Biological Psychiatry, 63(2), 245-7.
Harada T, et al. Obestatin, Acyl Ghrelin, and Des-acyl Ghrelin Responses to an Oral Glucose Tolerance Test in the Restricting Type of Anorexia Nervosa. Biol Psychiatry. 2008 Jan 15;63(2):245-7. PubMed PMID: 17706613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa. AU - Harada,Toshiro, AU - Nakahara,Toshihiro, AU - Yasuhara,Daisuke, AU - Kojima,Shinya, AU - Sagiyama,Ken-ichiro, AU - Amitani,Haruka, AU - Laviano,Alessandro, AU - Naruo,Tetsuro, AU - Inui,Akio, Y1 - 2007/08/16/ PY - 2007/01/23/received PY - 2007/03/12/revised PY - 2007/04/06/accepted PY - 2007/8/21/pubmed PY - 2008/2/28/medline PY - 2007/8/21/entrez SP - 245 EP - 7 JF - Biological psychiatry JO - Biol. Psychiatry VL - 63 IS - 2 N2 - BACKGROUND: Obestatin is a recently identified peptide encoded by the same ghrelin gene. It has been reported that obestatin has anorexigenic and antigastroprokinetic activities as opposed to ghrelin. We investigated simultaneously obestatin, acyl ghrelin, and des-acyl ghrelin in the restricting type of anorexia nervosa (AN-R) patients. METHODS: Three hormonal responses to the oral glucose tolerance test (OGTT) were measured in 10 AN-R patients and 10 healthy women. RESULTS: Plasma obestatin, acyl ghrelin, and des-acyl ghrelin levels were significantly higher in AN-R patients than in control subjects throughout the OGTT. All of the three hormones decreased after the OGTT in both groups. CONCLUSIONS: We found that AN-R patients exhibited increased plasma levels of obestatin, acyl ghrelin, and des-acyl ghrelin throughout the OGTT compared with control subjects. The hormonal differences between groups are statistically most significant in obestatin, suggesting obestatin may serve as a marker reflecting both acute and chronic changes of the nutritional state in AN-R patients. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/17706613/Obestatin_acyl_ghrelin_and_des_acyl_ghrelin_responses_to_an_oral_glucose_tolerance_test_in_the_restricting_type_of_anorexia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(07)00328-9 DB - PRIME DP - Unbound Medicine ER -