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A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT.
J Affect Disord. 2007 Nov; 103(1-3):277-81.JA

Abstract

BACKGROUND

Electroconvulsive therapy (ECT) is a highly effective treatment for depression but its use is limited by the risk of cognitive side effects. This study explored the potential of a novel approach, ultrabrief pulsewidth (0.3 ms) right unilateral (RUL-UB) ECT, to minimise cognitive effects while preserving efficacy.

METHODS

Mood and neuropsychological functioning were objectively rated in 30 patients over a course of RUL-UB ECT at 6 times seizure threshold. Results (mood outcomes, ECT treatment parameters) were compared with a retrospectively assessed group of 30 age and gender matched patients who received RUL ECT (1.0 ms pulsewidth, 3.5 times seizure threshold) at the same hospital.

RESULTS

Six treatments of RUL-UB ECT resulted in relatively few cognitive side effects, compared to reports of previous studies. The number of responders did not differ between groups but significantly more treatments were required in the RUL-UB group, suggesting a slower speed of response.

LIMITATIONS

Patients were not randomised to the two forms of ECT and data was obtained retrospectively in the RUL ECT comparison group.

CONCLUSIONS

This study suggests that RUL-UB ECT can be effective in treating depression while incurring lesser cognitive side effects than a commonly used form of RUL ECT, but a greater number of treatments may be required for response.

Authors+Show Affiliations

School of Psychiatry, University of N.S.W., Australia. colleen.loo@unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17706790

Citation

Loo, Colleen, et al. "A Report On Mood and Cognitive Outcomes With Right Unilateral Ultrabrief Pulsewidth (0.3 Ms) ECT and Retrospective Comparison With Standard Pulsewidth Right Unilateral ECT." Journal of Affective Disorders, vol. 103, no. 1-3, 2007, pp. 277-81.
Loo C, Sheehan P, Pigot M, et al. A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT. J Affect Disord. 2007;103(1-3):277-81.
Loo, C., Sheehan, P., Pigot, M., & Lyndon, W. (2007). A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT. Journal of Affective Disorders, 103(1-3), 277-81.
Loo C, et al. A Report On Mood and Cognitive Outcomes With Right Unilateral Ultrabrief Pulsewidth (0.3 Ms) ECT and Retrospective Comparison With Standard Pulsewidth Right Unilateral ECT. J Affect Disord. 2007;103(1-3):277-81. PubMed PMID: 17706790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT. AU - Loo,Colleen, AU - Sheehan,Patrick, AU - Pigot,Melissa, AU - Lyndon,William, Y1 - 2007/08/16/ PY - 2007/05/11/received PY - 2007/06/26/revised PY - 2007/06/26/accepted PY - 2007/8/21/pubmed PY - 2008/2/8/medline PY - 2007/8/21/entrez SP - 277 EP - 81 JF - Journal of affective disorders JO - J Affect Disord VL - 103 IS - 1-3 N2 - BACKGROUND: Electroconvulsive therapy (ECT) is a highly effective treatment for depression but its use is limited by the risk of cognitive side effects. This study explored the potential of a novel approach, ultrabrief pulsewidth (0.3 ms) right unilateral (RUL-UB) ECT, to minimise cognitive effects while preserving efficacy. METHODS: Mood and neuropsychological functioning were objectively rated in 30 patients over a course of RUL-UB ECT at 6 times seizure threshold. Results (mood outcomes, ECT treatment parameters) were compared with a retrospectively assessed group of 30 age and gender matched patients who received RUL ECT (1.0 ms pulsewidth, 3.5 times seizure threshold) at the same hospital. RESULTS: Six treatments of RUL-UB ECT resulted in relatively few cognitive side effects, compared to reports of previous studies. The number of responders did not differ between groups but significantly more treatments were required in the RUL-UB group, suggesting a slower speed of response. LIMITATIONS: Patients were not randomised to the two forms of ECT and data was obtained retrospectively in the RUL ECT comparison group. CONCLUSIONS: This study suggests that RUL-UB ECT can be effective in treating depression while incurring lesser cognitive side effects than a commonly used form of RUL ECT, but a greater number of treatments may be required for response. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/17706790/A_report_on_mood_and_cognitive_outcomes_with_right_unilateral_ultrabrief_pulsewidth__0_3_ms__ECT_and_retrospective_comparison_with_standard_pulsewidth_right_unilateral_ECT_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(07)00251-0 DB - PRIME DP - Unbound Medicine ER -