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Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study.
J Control Release. 2007 Sep 26; 122(2):199-205.JC

Abstract

The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear magnetic resonance (NMR) imaging revealed in situ the swelling behavior of tablets when exposed to water. By using deuterated water, the spatial distribution and molecular dynamics of HPMC and their kinetics during swelling could be observed selectively. In parallel, NMR spectroscopy provided the concentration of the drug released into the aqueous phase. We find that both swelling and release are diffusion controlled. The ability of monitoring those two processes using the same experimental setup enables mapping their interconnection, which points on the importance and potential of this analytical technique for further application in other drug delivery forms.

Authors+Show Affiliations

YKI, Institute for Surface Chemistry, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17706829

Citation

Dahlberg, Carina, et al. "Polymer Mobilization and Drug Release During Tablet Swelling. a 1H NMR and NMR Microimaging Study." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 122, no. 2, 2007, pp. 199-205.
Dahlberg C, Fureby A, Schuleit M, et al. Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study. J Control Release. 2007;122(2):199-205.
Dahlberg, C., Fureby, A., Schuleit, M., Dvinskikh, S. V., & Furó, I. (2007). Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study. Journal of Controlled Release : Official Journal of the Controlled Release Society, 122(2), 199-205.
Dahlberg C, et al. Polymer Mobilization and Drug Release During Tablet Swelling. a 1H NMR and NMR Microimaging Study. J Control Release. 2007 Sep 26;122(2):199-205. PubMed PMID: 17706829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study. AU - Dahlberg,Carina, AU - Fureby,Anna, AU - Schuleit,Michael, AU - Dvinskikh,Sergey V, AU - Furó,István, Y1 - 2007/07/25/ PY - 2007/05/16/received PY - 2007/07/03/revised PY - 2007/07/16/accepted PY - 2007/8/21/pubmed PY - 2007/9/21/medline PY - 2007/8/21/entrez SP - 199 EP - 205 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 122 IS - 2 N2 - The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear magnetic resonance (NMR) imaging revealed in situ the swelling behavior of tablets when exposed to water. By using deuterated water, the spatial distribution and molecular dynamics of HPMC and their kinetics during swelling could be observed selectively. In parallel, NMR spectroscopy provided the concentration of the drug released into the aqueous phase. We find that both swelling and release are diffusion controlled. The ability of monitoring those two processes using the same experimental setup enables mapping their interconnection, which points on the importance and potential of this analytical technique for further application in other drug delivery forms. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/17706829/Polymer_mobilization_and_drug_release_during_tablet_swelling__A_1H_NMR_and_NMR_microimaging_study_ DB - PRIME DP - Unbound Medicine ER -