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Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus).
Environ Pollut. 2008 Apr; 152(3):621-9.EP

Abstract

Congener patterns of the major organohalogen contaminant classes of PCBs, PBDEs and their metabolites and/or by-products (OH-PCBs, MeSO2-PCBs, OH-PBDEs and MeO-PBDEs) were examined in adipose tissue, liver, brain and blood of East Greenland polar bears (Ursus maritimus). PCB, OH-PCB, MeSO2-PCB and PBDE congener patterns showed significant differences (p<or=0.05) mainly in the liver and the brain relative to the adipose tissue and the blood. OH-PBDEs and MeO-PBDEs were not detected in the brain and liver, but had different patterns in blood versus the adipose tissue. Novel OH-polybrominated biphenyls (OH-PBBs), one tri- and two tetra-brominated OH-PBBs were detected in all tissues and blood. Congener pattern differences among tissues and blood are likely due to a combination of factors, e.g., biotransformation and retention in the liver, retention in the blood and blood-brain barrier transport. Our findings suggest that different congener pattern exposures to these classes of contaminants should be considered with respect to potential target tissue-specific effects in East Greenland polar bears.

Authors+Show Affiliations

National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Department of Chemistry, Carleton University, Ottawa, Ontario K1S 5B6, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17707109

Citation

Gebbink, Wouter A., et al. "Tissue-specific Congener Composition of Organohalogen and Metabolite Contaminants in East Greenland Polar Bears (Ursus Maritimus)." Environmental Pollution (Barking, Essex : 1987), vol. 152, no. 3, 2008, pp. 621-9.
Gebbink WA, Sonne C, Dietz R, et al. Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environ Pollut. 2008;152(3):621-9.
Gebbink, W. A., Sonne, C., Dietz, R., Kirkegaard, M., Riget, F. F., Born, E. W., Muir, D. C., & Letcher, R. J. (2008). Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environmental Pollution (Barking, Essex : 1987), 152(3), 621-9.
Gebbink WA, et al. Tissue-specific Congener Composition of Organohalogen and Metabolite Contaminants in East Greenland Polar Bears (Ursus Maritimus). Environ Pollut. 2008;152(3):621-9. PubMed PMID: 17707109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). AU - Gebbink,Wouter A, AU - Sonne,Christian, AU - Dietz,Rune, AU - Kirkegaard,Maja, AU - Riget,Frank F, AU - Born,Erik W, AU - Muir,Derek C G, AU - Letcher,Robert J, Y1 - 2007/08/16/ PY - 2007/02/20/received PY - 2007/06/29/revised PY - 2007/07/03/accepted PY - 2007/8/21/pubmed PY - 2008/9/20/medline PY - 2007/8/21/entrez SP - 621 EP - 9 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 152 IS - 3 N2 - Congener patterns of the major organohalogen contaminant classes of PCBs, PBDEs and their metabolites and/or by-products (OH-PCBs, MeSO2-PCBs, OH-PBDEs and MeO-PBDEs) were examined in adipose tissue, liver, brain and blood of East Greenland polar bears (Ursus maritimus). PCB, OH-PCB, MeSO2-PCB and PBDE congener patterns showed significant differences (p<or=0.05) mainly in the liver and the brain relative to the adipose tissue and the blood. OH-PBDEs and MeO-PBDEs were not detected in the brain and liver, but had different patterns in blood versus the adipose tissue. Novel OH-polybrominated biphenyls (OH-PBBs), one tri- and two tetra-brominated OH-PBBs were detected in all tissues and blood. Congener pattern differences among tissues and blood are likely due to a combination of factors, e.g., biotransformation and retention in the liver, retention in the blood and blood-brain barrier transport. Our findings suggest that different congener pattern exposures to these classes of contaminants should be considered with respect to potential target tissue-specific effects in East Greenland polar bears. SN - 0269-7491 UR - https://www.unboundmedicine.com/medline/citation/17707109/Tissue_specific_congener_composition_of_organohalogen_and_metabolite_contaminants_in_East_Greenland_polar_bears__Ursus_maritimus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(07)00343-0 DB - PRIME DP - Unbound Medicine ER -