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Metallosensors, the ups and downs of gene regulation.
Adv Microb Physiol. 2008; 53:231-67.AM

Abstract

In fungal cells, transcriptional regulatory mechanisms play a central role in both the homeostatic regulation of the essential metals iron, copper and zinc and in the detoxification of heavy metal ions such as cadmium. Fungi detect changes in metal ion levels using unique metallo-regulatory factors whose activity is responsive to the cellular metal ion status. New studies have revealed that these factors not only regulate the expression of genes required for metal ion acquisition, storage or detoxification but also globally remodel metabolism to conserve metal ions or protect against metal toxicity. This review focuses on the mechanisms metallo-regulators use to up- and down-regulate gene expression.

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Publisher Full Text

Authors+Show Affiliations

Bird AJ
Division of Hematology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.

MeSH

Gene Expression Regulation, FungalMetals, HeavySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, Genetic

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17707146

Citation

Bird, Amanda J.. "Metallosensors, the Ups and Downs of Gene Regulation." Advances in Microbial Physiology, vol. 53, 2008, pp. 231-67.
Bird AJ. Metallosensors, the ups and downs of gene regulation. Adv Microb Physiol. 2008;53:231-67.
Bird, A. J. (2008). Metallosensors, the ups and downs of gene regulation. Advances in Microbial Physiology, 53, 231-67.
Bird AJ. Metallosensors, the Ups and Downs of Gene Regulation. Adv Microb Physiol. 2008;53:231-67. PubMed PMID: 17707146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metallosensors, the ups and downs of gene regulation. A1 - Bird,Amanda J, PY - 2007/8/21/pubmed PY - 2007/12/12/medline PY - 2007/8/21/entrez SP - 231 EP - 67 JF - Advances in microbial physiology JO - Adv Microb Physiol VL - 53 N2 - In fungal cells, transcriptional regulatory mechanisms play a central role in both the homeostatic regulation of the essential metals iron, copper and zinc and in the detoxification of heavy metal ions such as cadmium. Fungi detect changes in metal ion levels using unique metallo-regulatory factors whose activity is responsive to the cellular metal ion status. New studies have revealed that these factors not only regulate the expression of genes required for metal ion acquisition, storage or detoxification but also globally remodel metabolism to conserve metal ions or protect against metal toxicity. This review focuses on the mechanisms metallo-regulators use to up- and down-regulate gene expression. SN - 0065-2911 UR - https://www.unboundmedicine.com/medline/citation/17707146/Metallosensors_the_ups_and_downs_of_gene_regulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0065-2911(07)53004-3 DB - PRIME DP - Unbound Medicine ER -