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Dorsal, ventral, and complete excitotoxic lesions of the hippocampus in rats failed to impair appetitive trace conditioning.
Behav Brain Res. 2007 Dec 11; 185(1):9-20.BB

Abstract

Three experiments examined appetitive trace and delay conditioning of the licking response (LR). In Experiment 1, normal rats were trained in trace conditioning using different trace intervals (2, 4, or 8s) and in delay conditioning (i.e., with a 0-s trace) in order to determine an appropriate trace interval for the following lesion experiments. Only the rats trained with a 2-s trace interval ultimately reached the same level of learning as rats trained in delay conditioning. In Experiments 2A and 2B, the performance of rats with dorsal, ventral, and complete excitotoxic hippocampal lesions was compared to that of sham-operated rats in LR conditioning with a 2-s trace. In Experiment 2B, the performance of rats in trace LR conditioning was also compared to that of rats tested in the delay paradigm. In both experiments, acquisition did not differ in lesioned and sham-operated rats and, in Experiment 2B, it was faster in the delay than in the trace paradigm. These results contrast with those showing that aversive trace conditioning is impaired after hippocampal damage. Experiment 3 examined whether the differential effects of hippocampal lesions on aversive and appetitive trace conditioning could be related to a parametric difference, that is, the relative durations of the conditional stimulus and of the trace interval. Again, hippocampal damage failed to produce a learning impairment. It is suggested that the procedure of aversive, but not of appetitive, trace conditioning is context-specific and that an intact hippocampus is required only in these situations.

Authors+Show Affiliations

Ecole de psychologie, Pavillon Félix-Antoine-Savard, Université Laval, Québec, Canada G1K 7P4.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17707920

Citation

Thibaudeau, Geneviève, et al. "Dorsal, Ventral, and Complete Excitotoxic Lesions of the Hippocampus in Rats Failed to Impair Appetitive Trace Conditioning." Behavioural Brain Research, vol. 185, no. 1, 2007, pp. 9-20.
Thibaudeau G, Potvin O, Allen K, et al. Dorsal, ventral, and complete excitotoxic lesions of the hippocampus in rats failed to impair appetitive trace conditioning. Behav Brain Res. 2007;185(1):9-20.
Thibaudeau, G., Potvin, O., Allen, K., Doré, F. Y., & Goulet, S. (2007). Dorsal, ventral, and complete excitotoxic lesions of the hippocampus in rats failed to impair appetitive trace conditioning. Behavioural Brain Research, 185(1), 9-20.
Thibaudeau G, et al. Dorsal, Ventral, and Complete Excitotoxic Lesions of the Hippocampus in Rats Failed to Impair Appetitive Trace Conditioning. Behav Brain Res. 2007 Dec 11;185(1):9-20. PubMed PMID: 17707920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal, ventral, and complete excitotoxic lesions of the hippocampus in rats failed to impair appetitive trace conditioning. AU - Thibaudeau,Geneviève, AU - Potvin,Olivier, AU - Allen,Kevin, AU - Doré,François Y, AU - Goulet,Sonia, Y1 - 2007/07/12/ PY - 2007/01/31/received PY - 2007/07/06/revised PY - 2007/07/09/accepted PY - 2007/8/21/pubmed PY - 2008/1/9/medline PY - 2007/8/21/entrez SP - 9 EP - 20 JF - Behavioural brain research JO - Behav Brain Res VL - 185 IS - 1 N2 - Three experiments examined appetitive trace and delay conditioning of the licking response (LR). In Experiment 1, normal rats were trained in trace conditioning using different trace intervals (2, 4, or 8s) and in delay conditioning (i.e., with a 0-s trace) in order to determine an appropriate trace interval for the following lesion experiments. Only the rats trained with a 2-s trace interval ultimately reached the same level of learning as rats trained in delay conditioning. In Experiments 2A and 2B, the performance of rats with dorsal, ventral, and complete excitotoxic hippocampal lesions was compared to that of sham-operated rats in LR conditioning with a 2-s trace. In Experiment 2B, the performance of rats in trace LR conditioning was also compared to that of rats tested in the delay paradigm. In both experiments, acquisition did not differ in lesioned and sham-operated rats and, in Experiment 2B, it was faster in the delay than in the trace paradigm. These results contrast with those showing that aversive trace conditioning is impaired after hippocampal damage. Experiment 3 examined whether the differential effects of hippocampal lesions on aversive and appetitive trace conditioning could be related to a parametric difference, that is, the relative durations of the conditional stimulus and of the trace interval. Again, hippocampal damage failed to produce a learning impairment. It is suggested that the procedure of aversive, but not of appetitive, trace conditioning is context-specific and that an intact hippocampus is required only in these situations. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/17707920/Dorsal_ventral_and_complete_excitotoxic_lesions_of_the_hippocampus_in_rats_failed_to_impair_appetitive_trace_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(07)00353-1 DB - PRIME DP - Unbound Medicine ER -