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Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli.
Reproduction. 2007 Sep; 134(3):513-23.R

Abstract

Homeobox A10 (HOXA10), a member of abdominal B subclass of homeobox genes, is responsible for uterine homeosis during development. Intriguingly, in the adult murine uterus, HOXA10 has been demonstrated to play important roles in receptivity, embryo implantation, and decidualization. However, the roles of HOXA10 in the primate endometrium are not known. To gain insights into the roles of HOXA10 in the primate endometrium, its expression was studied in the endometria of bonnet monkey (Macaca radiata) in the receptive phase and also in the endometria of monkeys treated with antiprogestin onapristone (ZK98.299) or in conception cycle where the presence of preimplantation stage blastocyst was verified. In addition, the mRNA expression of HOXA11 and insulin-like growth factor-binding protein 1 (IGFBP1) was evaluated by real-time PCR in these animals.The results revealed that HOXA10 in the luteal phase primate endometrium is differentially expressed in the functionalis and the basalis zones, which is modulated in vivo by progesterone and also by the signals from the incoming embryo suggesting the involvement of HOXA10 in the process of establishment of pregnancy in primates. In addition, the results also demonstrated that the expression of IGFBP1 but not HOXA11 is coregulated with HOXA10 in the endometria of these animals. The pattern of changes in the expression of HOXA10 in response to the two stimuli suggests that endometrial receptivity and implantation not only requires a synchrony of maternal and embryonic signaling on endometrial cells in the primates but there also exists a controlled differential response among the cells of various uterine compartments.

Authors+Show Affiliations

National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400012, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17709569

Citation

Godbole, G B., et al. "Regulation of Homeobox A10 Expression in the Primate Endometrium By Progesterone and Embryonic Stimuli." Reproduction (Cambridge, England), vol. 134, no. 3, 2007, pp. 513-23.
Godbole GB, Modi DN, Puri CP. Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. Reproduction. 2007;134(3):513-23.
Godbole, G. B., Modi, D. N., & Puri, C. P. (2007). Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. Reproduction (Cambridge, England), 134(3), 513-23.
Godbole GB, Modi DN, Puri CP. Regulation of Homeobox A10 Expression in the Primate Endometrium By Progesterone and Embryonic Stimuli. Reproduction. 2007;134(3):513-23. PubMed PMID: 17709569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. AU - Godbole,G B, AU - Modi,D N, AU - Puri,C P, PY - 2007/8/22/pubmed PY - 2007/12/6/medline PY - 2007/8/22/entrez SP - 513 EP - 23 JF - Reproduction (Cambridge, England) JO - Reproduction VL - 134 IS - 3 N2 - Homeobox A10 (HOXA10), a member of abdominal B subclass of homeobox genes, is responsible for uterine homeosis during development. Intriguingly, in the adult murine uterus, HOXA10 has been demonstrated to play important roles in receptivity, embryo implantation, and decidualization. However, the roles of HOXA10 in the primate endometrium are not known. To gain insights into the roles of HOXA10 in the primate endometrium, its expression was studied in the endometria of bonnet monkey (Macaca radiata) in the receptive phase and also in the endometria of monkeys treated with antiprogestin onapristone (ZK98.299) or in conception cycle where the presence of preimplantation stage blastocyst was verified. In addition, the mRNA expression of HOXA11 and insulin-like growth factor-binding protein 1 (IGFBP1) was evaluated by real-time PCR in these animals.The results revealed that HOXA10 in the luteal phase primate endometrium is differentially expressed in the functionalis and the basalis zones, which is modulated in vivo by progesterone and also by the signals from the incoming embryo suggesting the involvement of HOXA10 in the process of establishment of pregnancy in primates. In addition, the results also demonstrated that the expression of IGFBP1 but not HOXA11 is coregulated with HOXA10 in the endometria of these animals. The pattern of changes in the expression of HOXA10 in response to the two stimuli suggests that endometrial receptivity and implantation not only requires a synchrony of maternal and embryonic signaling on endometrial cells in the primates but there also exists a controlled differential response among the cells of various uterine compartments. SN - 1470-1626 UR - https://www.unboundmedicine.com/medline/citation/17709569/Regulation_of_homeobox_A10_expression_in_the_primate_endometrium_by_progesterone_and_embryonic_stimuli_ L2 - https://rep.bioscientifica.com/doi/10.1530/REP-07-0234 DB - PRIME DP - Unbound Medicine ER -