TY - JOUR T1 - Highly enantioselective Michael additions in water catalyzed by a PS-supported pyrrolidine. AU - Alza,Esther, AU - Cambeiro,Xacobe C, AU - Jimeno,Ciril, AU - Pericàs,Miquel A, Y1 - 2007/08/21/ PY - 2007/8/23/pubmed PY - 2007/8/23/medline PY - 2007/8/23/entrez SP - 3717 EP - 20 JF - Organic letters JO - Org Lett VL - 9 IS - 19 N2 - The development of a highly efficient, polymer-supported organocatalyst for the Michael addition of ketones to nitroolefins is described. A 1,2,3-triazole ring, constructed through a click 1,3-cycloaddition, plays the double role of grafting the chiral pyrrolidine monomer onto the polystyrene backbone and of providing a structural element, complementary to pyrrolidine, key to high catalytic activity and enantioselectivity. Optimal operation in water and full recyclability make the triazole linker attractive for the immobilization of organocatalysts. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/17711288/Highly_enantioselective_Michael_additions_in_water_catalyzed_by_a_PS_supported_pyrrolidine_ L2 - https://doi.org/10.1021/ol071366k DB - PRIME DP - Unbound Medicine ER -