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Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis.
Allergy 2007; 62(11):1257-60A

Abstract

BACKGROUND

Eosinophilic esophagitis (EE) is an emerging condition where patients commonly present with symptoms of gastroesophageal reflux disease and fail to respond adequately to anti-reflux therapy. Food allergy is currently recognized as the main immunological cause of EE; recent evidence suggests an etiological role for inhalant allergens. The presence of EE appears to be associated with other atopic illnesses.

OBJECTIVES

To report the sensitization profile of both food and inhalant allergens in our EE patient cohort in relation to age, and to profile the prevalence of other allergic conditions in patients with EE.

METHOD

The study prospectively analyzed allergen sensitization profiles using skin prick tests to common food allergens and inhalant allergens in 45 children with EE. Patch testing to common food allergens was performed on 33 patients in the same cohort. Comorbidity of atopic eczema, asthma, allergic rhinitis and anaphylaxis were obtained from patient history.

RESULTS

Younger patients with EE showed more IgE and patch sensitization to foods while older patients showed greater IgE sensitization to inhalant allergens. The prevalence of atopic eczema, allergic rhinitis and asthma was significantly increased in our EE cohort compared with the general Australian population. A total of 24% of our cohort of patients with EE had a history of anaphylaxis.

CONCLUSION

In children with EE, the sensitization to inhalant allergens increases with age, particularly after 4 years. Also, specific enquiry about severe food reactions in patients presenting with EE is strongly recommended as it appears this patient group has a high incidence of anaphylaxis.

Authors+Show Affiliations

Medical School, Griffith University, Southport, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17711545

Citation

Sugnanam, K K N., et al. "Dichotomy of Food and Inhalant Allergen Sensitization in Eosinophilic Esophagitis." Allergy, vol. 62, no. 11, 2007, pp. 1257-60.
Sugnanam KK, Collins JT, Smith PK, et al. Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy. 2007;62(11):1257-60.
Sugnanam, K. K., Collins, J. T., Smith, P. K., Connor, F., Lewindon, P., Cleghorn, G., & Withers, G. (2007). Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy, 62(11), pp. 1257-60.
Sugnanam KK, et al. Dichotomy of Food and Inhalant Allergen Sensitization in Eosinophilic Esophagitis. Allergy. 2007;62(11):1257-60. PubMed PMID: 17711545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. AU - Sugnanam,K K N, AU - Collins,J T, AU - Smith,P K, AU - Connor,F, AU - Lewindon,P, AU - Cleghorn,G, AU - Withers,G, Y1 - 2007/08/17/ PY - 2007/8/23/pubmed PY - 2008/1/30/medline PY - 2007/8/23/entrez SP - 1257 EP - 60 JF - Allergy JO - Allergy VL - 62 IS - 11 N2 - BACKGROUND: Eosinophilic esophagitis (EE) is an emerging condition where patients commonly present with symptoms of gastroesophageal reflux disease and fail to respond adequately to anti-reflux therapy. Food allergy is currently recognized as the main immunological cause of EE; recent evidence suggests an etiological role for inhalant allergens. The presence of EE appears to be associated with other atopic illnesses. OBJECTIVES: To report the sensitization profile of both food and inhalant allergens in our EE patient cohort in relation to age, and to profile the prevalence of other allergic conditions in patients with EE. METHOD: The study prospectively analyzed allergen sensitization profiles using skin prick tests to common food allergens and inhalant allergens in 45 children with EE. Patch testing to common food allergens was performed on 33 patients in the same cohort. Comorbidity of atopic eczema, asthma, allergic rhinitis and anaphylaxis were obtained from patient history. RESULTS: Younger patients with EE showed more IgE and patch sensitization to foods while older patients showed greater IgE sensitization to inhalant allergens. The prevalence of atopic eczema, allergic rhinitis and asthma was significantly increased in our EE cohort compared with the general Australian population. A total of 24% of our cohort of patients with EE had a history of anaphylaxis. CONCLUSION: In children with EE, the sensitization to inhalant allergens increases with age, particularly after 4 years. Also, specific enquiry about severe food reactions in patients presenting with EE is strongly recommended as it appears this patient group has a high incidence of anaphylaxis. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/17711545/Dichotomy_of_food_and_inhalant_allergen_sensitization_in_eosinophilic_esophagitis_ L2 - https://doi.org/10.1111/j.1398-9995.2007.01454.x DB - PRIME DP - Unbound Medicine ER -