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[Clinical and angiographic outcome in coronary artery disease patients with type-II diabetes mellitus undergoing elective bare-metal stenting or drug-eluting stenting].
Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Jun; 35(6):523-6.ZX

Abstract

OBJECTIVE

To compare the clinical and angiographic outcome in patients with type-II diabetes mellitus undergoing drug-eluting stent (DES) or bare-metal stent (BMS).

METHODS

A total of 139 consecutive diabetic patients (114 males) with coronary disease who underwent successful elective percutaneous coronary intervention with DES (n = 83 with 151 lesions) or BMS (n = 56 with 70 lesions) on native coronary arteries from April 2004 to August 2005 at our institution were included in this study. All patients were treated according to guidelines and coronary angiography was repeated at 6 months post procedure in all patients. Aspirin (300 mg/d) and clopidogrel (75 mg/d) were administered till 6 months after the procedure.

RESULTS

There were 42.5% C type by ACC/AHA and 19.0% total occlusion lesions. The average stent length of each lesion was 26.53 +/- 14.72 mm, and mean reference diameter was 2.80 +/- 0.43 mm. Baseline characteristics were similar between DES and BMS groups except lower mean reference vessel diameter in DES than that of BMS group (2.71 +/- 0.41 mm vs. 2.98 +/- 0.53 mm, P < 0.001). The in stent restenosis rate at 6 months (10.6% vs. 38.6%, P < 0.001) and in-segment late loss (0.24 +/- 0.56 mm vs. 0.91 +/- 0.77 mm, P < 0.001) were significantly lower in DES group than those of BMS group. The target lesion revascularization (TLR) incidence was also significantly lower in DES group compared to BMS group (8.6% vs. 30.0%, P < 0.001). However, 4 late in-stent thrombosis were seen in DES group and none in BMS group of DES (P = 0.148).

CONCLUSION

DES implantation in patients with diabetes mellitus is associated with lower in-stent restenosis and TLR rates compared to BMS implantation 6 months after procedure and attention should be paid on late in-stent thrombosis after DES implantation.

Authors+Show Affiliations

Coronary Heart Disease Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Email: qiaosb1@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

chi

PubMed ID

17711711

Citation

Qiao, Shu-bin, et al. "[Clinical and Angiographic Outcome in Coronary Artery Disease Patients With type-II Diabetes Mellitus Undergoing Elective Bare-metal Stenting or Drug-eluting Stenting]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 35, no. 6, 2007, pp. 523-6.
Qiao SB, Hou Q, Xu B, et al. [Clinical and angiographic outcome in coronary artery disease patients with type-II diabetes mellitus undergoing elective bare-metal stenting or drug-eluting stenting]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35(6):523-6.
Qiao, S. B., Hou, Q., Xu, B., Chen, J., Liu, H. B., Yang, Y. J., Wu, Y. J., Yuan, J. Q., Wu, Y., Dai, J., You, S. J., Ma, W. H., Zhang, P., Gao, Z., Dou, K. F., Qiu, H., Mu, C. W., Chen, J. L., & Gao, R. L. (2007). [Clinical and angiographic outcome in coronary artery disease patients with type-II diabetes mellitus undergoing elective bare-metal stenting or drug-eluting stenting]. Zhonghua Xin Xue Guan Bing Za Zhi, 35(6), 523-6.
Qiao SB, et al. [Clinical and Angiographic Outcome in Coronary Artery Disease Patients With type-II Diabetes Mellitus Undergoing Elective Bare-metal Stenting or Drug-eluting Stenting]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35(6):523-6. PubMed PMID: 17711711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical and angiographic outcome in coronary artery disease patients with type-II diabetes mellitus undergoing elective bare-metal stenting or drug-eluting stenting]. AU - Qiao,Shu-bin, AU - Hou,Qing, AU - Xu,Bo, AU - Chen,Jue, AU - Liu,Hai-bo, AU - Yang,Yue-jin, AU - Wu,Yong-jian, AU - Yuan,Jin-qing, AU - Wu,Yuan, AU - Dai,Jun, AU - You,Shi-jie, AU - Ma,Wei-hua, AU - Zhang,Pei, AU - Gao,Zhan, AU - Dou,Ke-fei, AU - Qiu,Hong, AU - Mu,Chao-wei, AU - Chen,Ji-lin, AU - Gao,Run-lin, PY - 2007/8/23/pubmed PY - 2009/8/12/medline PY - 2007/8/23/entrez SP - 523 EP - 6 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 35 IS - 6 N2 - OBJECTIVE: To compare the clinical and angiographic outcome in patients with type-II diabetes mellitus undergoing drug-eluting stent (DES) or bare-metal stent (BMS). METHODS: A total of 139 consecutive diabetic patients (114 males) with coronary disease who underwent successful elective percutaneous coronary intervention with DES (n = 83 with 151 lesions) or BMS (n = 56 with 70 lesions) on native coronary arteries from April 2004 to August 2005 at our institution were included in this study. All patients were treated according to guidelines and coronary angiography was repeated at 6 months post procedure in all patients. Aspirin (300 mg/d) and clopidogrel (75 mg/d) were administered till 6 months after the procedure. RESULTS: There were 42.5% C type by ACC/AHA and 19.0% total occlusion lesions. The average stent length of each lesion was 26.53 +/- 14.72 mm, and mean reference diameter was 2.80 +/- 0.43 mm. Baseline characteristics were similar between DES and BMS groups except lower mean reference vessel diameter in DES than that of BMS group (2.71 +/- 0.41 mm vs. 2.98 +/- 0.53 mm, P < 0.001). The in stent restenosis rate at 6 months (10.6% vs. 38.6%, P < 0.001) and in-segment late loss (0.24 +/- 0.56 mm vs. 0.91 +/- 0.77 mm, P < 0.001) were significantly lower in DES group than those of BMS group. The target lesion revascularization (TLR) incidence was also significantly lower in DES group compared to BMS group (8.6% vs. 30.0%, P < 0.001). However, 4 late in-stent thrombosis were seen in DES group and none in BMS group of DES (P = 0.148). CONCLUSION: DES implantation in patients with diabetes mellitus is associated with lower in-stent restenosis and TLR rates compared to BMS implantation 6 months after procedure and attention should be paid on late in-stent thrombosis after DES implantation. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/17711711/[Clinical_and_angiographic_outcome_in_coronary_artery_disease_patients_with_type_II_diabetes_mellitus_undergoing_elective_bare_metal_stenting_or_drug_eluting_stenting]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2007&amp;vol=35&amp;issue=6&amp;fpage=523 DB - PRIME DP - Unbound Medicine ER -