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Amylin and its relation to insulin and lipids in obese children before and after weight loss.
Obesity (Silver Spring). 2007 Aug; 15(8):2006-11.O

Abstract

OBJECTIVE

There are limited data concerning the relationships between amylin, weight status, lipids, insulin, and insulin resistance in obese humans. Therefore, the aim was to study these relationships in cross-sectional and longitudinal analyses.

RESEARCH METHODS AND PROCEDURES

Fasting amylin, insulin, glucose, triglycerides, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, and percentage body fat based on skinfold measurements were determined in 37 obese children (median age, 11.5 years) and compared with 16 lean children of the same age and gender. Furthermore, we analyzed the changes of these variables in the obese children after participating in a one-year weight loss intervention program.

RESULTS

Obese children had significantly (p < 0.01) higher amylin, triglycerides, LDL-cholesterol, and insulin levels as compared with the lean children. In multiple linear regression analysis, amylin was significantly (p < 0.05) correlated to insulin and triglycerides, but not to age, gender, pubertal stage, or BMI. Changes of amylin correlated significantly (p < 0.001) to changes of insulin (r = 0.54) and triglycerides (r = 0.49), but not to changes of BMI or percentage body fat. Substantial weight loss in 17 children led to a significant (p < 0.05) decrease of amylin, triglycerides, and insulin, in contrast to the 20 children without substantial weight loss.

CONCLUSION

Amylin levels were related to insulin concentrations in both cross-sectional and longitudinal analyses, suggesting a relationship between amylin and insulin secretion. Amylin levels were reversibly increased in obesity and related to triglyceride concentrations.

Authors+Show Affiliations

Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Dr. F. Steiner Str. 5, 45711 Datteln, Germany. T.Reinehr@kinderklinik-datteln.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17712118

Citation

Reinehr, Thomas, et al. "Amylin and Its Relation to Insulin and Lipids in Obese Children Before and After Weight Loss." Obesity (Silver Spring, Md.), vol. 15, no. 8, 2007, pp. 2006-11.
Reinehr T, de Sousa G, Niklowitz P, et al. Amylin and its relation to insulin and lipids in obese children before and after weight loss. Obesity (Silver Spring). 2007;15(8):2006-11.
Reinehr, T., de Sousa, G., Niklowitz, P., & Roth, C. L. (2007). Amylin and its relation to insulin and lipids in obese children before and after weight loss. Obesity (Silver Spring, Md.), 15(8), 2006-11.
Reinehr T, et al. Amylin and Its Relation to Insulin and Lipids in Obese Children Before and After Weight Loss. Obesity (Silver Spring). 2007;15(8):2006-11. PubMed PMID: 17712118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amylin and its relation to insulin and lipids in obese children before and after weight loss. AU - Reinehr,Thomas, AU - de Sousa,Gideon, AU - Niklowitz,Petra, AU - Roth,Christian L, PY - 2007/8/23/pubmed PY - 2007/11/6/medline PY - 2007/8/23/entrez SP - 2006 EP - 11 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 15 IS - 8 N2 - OBJECTIVE: There are limited data concerning the relationships between amylin, weight status, lipids, insulin, and insulin resistance in obese humans. Therefore, the aim was to study these relationships in cross-sectional and longitudinal analyses. RESEARCH METHODS AND PROCEDURES: Fasting amylin, insulin, glucose, triglycerides, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, and percentage body fat based on skinfold measurements were determined in 37 obese children (median age, 11.5 years) and compared with 16 lean children of the same age and gender. Furthermore, we analyzed the changes of these variables in the obese children after participating in a one-year weight loss intervention program. RESULTS: Obese children had significantly (p < 0.01) higher amylin, triglycerides, LDL-cholesterol, and insulin levels as compared with the lean children. In multiple linear regression analysis, amylin was significantly (p < 0.05) correlated to insulin and triglycerides, but not to age, gender, pubertal stage, or BMI. Changes of amylin correlated significantly (p < 0.001) to changes of insulin (r = 0.54) and triglycerides (r = 0.49), but not to changes of BMI or percentage body fat. Substantial weight loss in 17 children led to a significant (p < 0.05) decrease of amylin, triglycerides, and insulin, in contrast to the 20 children without substantial weight loss. CONCLUSION: Amylin levels were related to insulin concentrations in both cross-sectional and longitudinal analyses, suggesting a relationship between amylin and insulin secretion. Amylin levels were reversibly increased in obesity and related to triglyceride concentrations. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17712118/Amylin_and_its_relation_to_insulin_and_lipids_in_obese_children_before_and_after_weight_loss_ L2 - https://doi.org/10.1038/oby.2007.239 DB - PRIME DP - Unbound Medicine ER -