Tags

Type your tag names separated by a space and hit enter

Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery.
Obesity (Silver Spring). 2007 Aug; 15(8):2012-8.O

Abstract

OBJECTIVE

The objective was to evaluate ghrelin and growth hormone (GH) interactions and responses to a growth hormone-releasing hormone (GHRH)/arginine test in severe obesity before and after surgically-induced weight loss.

RESEARCH METHODS AND PROCEDURES

Our study population included 11 severely obese women 39 +/- 12 years of age, with a mean BMI of 48.6 +/- 2.4 kg/m2, re-studied in a phase of stabilized body weight, with a BMI of 33.4 +/- 1.2 kg/m2, 18 months after having successfully undergone biliopancreatic diversion (BPD). A GHRH/arginine test was performed before and 18 months after BPD to evaluate ghrelin and GH interactions. Active ghrelin, measured by radioimmunoassay (RIA), and GH, measured by chemiluminescence assay, were assayed before and after the GHRH/arginine test.

RESULTS

Fasting serum GH levels and GH area under the curve (AUC) significantly increased from 0.2 +/- 0.05 ng/mL to 1 +/- 0.3 ng/mL (p < 0.05) and from 514.76 +/- 98.7 ng/mL for 120 minutes to 1957.3 +/- 665.1 ng/mL for 120 minutes after bariatric surgery (p < 0.05), respectively. Although no significant change in fasting ghrelin levels was observed (573 +/- 77.9 before BPD vs. 574.1 +/- 32.7 after BPD), ghrelin AUC significantly increased from -3253.9 +/- 2180.9 pg/mL for 120 minutes to 1142.3 +/- 916.4 pg/mL for 120 minutes after BPD (p < 0.05). Fasting serum insulin-like growth factor (IGF)-1 concentration did not change significantly (133.6 +/- 9.9 ng/mL before vs. 153.3 +/- 25.2 ng/mL after BPD).

DISCUSSION

Our study demonstrates that the mechanisms involved in ghrelin and GH secretion after the secretagogue stimulus (GHRH/arginine) are consistent with patterns observed in other populations.

Authors+Show Affiliations

Department of Internal Medicine, Metabolic Unit, Università Cattolica S. Cuore, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17712119

Citation

Valera Mora, Maria E., et al. "Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery." Obesity (Silver Spring, Md.), vol. 15, no. 8, 2007, pp. 2012-8.
Valera Mora ME, Manco M, Capristo E, et al. Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery. Obesity (Silver Spring). 2007;15(8):2012-8.
Valera Mora, M. E., Manco, M., Capristo, E., Guidone, C., Iaconelli, A., Gniuli, D., Rosa, G., Calvani, M., & Mingrone, G. (2007). Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery. Obesity (Silver Spring, Md.), 15(8), 2012-8.
Valera Mora ME, et al. Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery. Obesity (Silver Spring). 2007;15(8):2012-8. PubMed PMID: 17712119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery. AU - Valera Mora,Maria E, AU - Manco,Melania, AU - Capristo,Esmeralda, AU - Guidone,Caterina, AU - Iaconelli,Amerigo, AU - Gniuli,Donatella, AU - Rosa,Giuseppina, AU - Calvani,Menotti, AU - Mingrone,Geltrude, PY - 2007/8/23/pubmed PY - 2007/11/6/medline PY - 2007/8/23/entrez SP - 2012 EP - 8 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 15 IS - 8 N2 - OBJECTIVE: The objective was to evaluate ghrelin and growth hormone (GH) interactions and responses to a growth hormone-releasing hormone (GHRH)/arginine test in severe obesity before and after surgically-induced weight loss. RESEARCH METHODS AND PROCEDURES: Our study population included 11 severely obese women 39 +/- 12 years of age, with a mean BMI of 48.6 +/- 2.4 kg/m2, re-studied in a phase of stabilized body weight, with a BMI of 33.4 +/- 1.2 kg/m2, 18 months after having successfully undergone biliopancreatic diversion (BPD). A GHRH/arginine test was performed before and 18 months after BPD to evaluate ghrelin and GH interactions. Active ghrelin, measured by radioimmunoassay (RIA), and GH, measured by chemiluminescence assay, were assayed before and after the GHRH/arginine test. RESULTS: Fasting serum GH levels and GH area under the curve (AUC) significantly increased from 0.2 +/- 0.05 ng/mL to 1 +/- 0.3 ng/mL (p < 0.05) and from 514.76 +/- 98.7 ng/mL for 120 minutes to 1957.3 +/- 665.1 ng/mL for 120 minutes after bariatric surgery (p < 0.05), respectively. Although no significant change in fasting ghrelin levels was observed (573 +/- 77.9 before BPD vs. 574.1 +/- 32.7 after BPD), ghrelin AUC significantly increased from -3253.9 +/- 2180.9 pg/mL for 120 minutes to 1142.3 +/- 916.4 pg/mL for 120 minutes after BPD (p < 0.05). Fasting serum insulin-like growth factor (IGF)-1 concentration did not change significantly (133.6 +/- 9.9 ng/mL before vs. 153.3 +/- 25.2 ng/mL after BPD). DISCUSSION: Our study demonstrates that the mechanisms involved in ghrelin and GH secretion after the secretagogue stimulus (GHRH/arginine) are consistent with patterns observed in other populations. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17712119/Growth_hormone_and_ghrelin_secretion_in_severely_obese_women_before_and_after_bariatric_surgery_ L2 - https://doi.org/10.1038/oby.2007.240 DB - PRIME DP - Unbound Medicine ER -