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Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine.
Chem Biodivers. 2007 Aug; 4(8):1729-43.CB

Abstract

Cannabis sativa L. has been utilized for treatment of pain and sleep disorders since ancient times. This review examines modern studies on effects of Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on sleep. It goes on to report new information on the effects on sleep in the context of medical treatment of neuropathic pain and symptoms of multiple sclerosis, employing standardized oromucosal cannabis-based medicines containing primarily THC, CBD, or a 1 : 1 combination of the two (Sativex). Sleep-laboratory results indicate a mild activating effect of CBD, and slight residual sedation with THC-predominant extracts. Experience to date with Sativex in numerous Phase I-III studies in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in patients with a wide variety of pain conditions including multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis, with an acceptable adverse event profile. No tolerance to the benefit of Sativex on pain or sleep, nor need for dosage increases have been noted in safety extension studies of up to four years, wherein 40-50% of subjects attained good or very good sleep quality, a key source of disability in chronic pain syndromes that may contribute to patients' quality of life.

Authors+Show Affiliations

GW Pharmaceuticals, Porton Down Science Park, Salisbury, Wiltshire SP4OJQ, UK. erusso@gwpharm.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17712817

Citation

Russo, Ethan B., et al. "Cannabis, Pain, and Sleep: Lessons From Therapeutic Clinical Trials of Sativex, a Cannabis-based Medicine." Chemistry & Biodiversity, vol. 4, no. 8, 2007, pp. 1729-43.
Russo EB, Guy GW, Robson PJ. Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chem Biodivers. 2007;4(8):1729-43.
Russo, E. B., Guy, G. W., & Robson, P. J. (2007). Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chemistry & Biodiversity, 4(8), 1729-43.
Russo EB, Guy GW, Robson PJ. Cannabis, Pain, and Sleep: Lessons From Therapeutic Clinical Trials of Sativex, a Cannabis-based Medicine. Chem Biodivers. 2007;4(8):1729-43. PubMed PMID: 17712817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. AU - Russo,Ethan B, AU - Guy,Geoffrey W, AU - Robson,Philip J, PY - 2007/8/23/pubmed PY - 2007/9/29/medline PY - 2007/8/23/entrez SP - 1729 EP - 43 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 4 IS - 8 N2 - Cannabis sativa L. has been utilized for treatment of pain and sleep disorders since ancient times. This review examines modern studies on effects of Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on sleep. It goes on to report new information on the effects on sleep in the context of medical treatment of neuropathic pain and symptoms of multiple sclerosis, employing standardized oromucosal cannabis-based medicines containing primarily THC, CBD, or a 1 : 1 combination of the two (Sativex). Sleep-laboratory results indicate a mild activating effect of CBD, and slight residual sedation with THC-predominant extracts. Experience to date with Sativex in numerous Phase I-III studies in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in patients with a wide variety of pain conditions including multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis, with an acceptable adverse event profile. No tolerance to the benefit of Sativex on pain or sleep, nor need for dosage increases have been noted in safety extension studies of up to four years, wherein 40-50% of subjects attained good or very good sleep quality, a key source of disability in chronic pain syndromes that may contribute to patients' quality of life. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/17712817/Cannabis_pain_and_sleep:_lessons_from_therapeutic_clinical_trials_of_Sativex_a_cannabis_based_medicine_ L2 - https://doi.org/10.1002/cbdv.200790150 DB - PRIME DP - Unbound Medicine ER -