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Decreased oral toxicity with the local use of allopurinol in patients who received high dose 5-fluorouracil.
Sel Cancer Ther. 1991 Fall; 7(3):113-7.SC

Abstract

5-Fluorouracil (5FU) is the most effective drug in gastrointestinal cancer. Mucositis and bone marrow toxicity are the two major limiting side effects. In our effort to reduce mucositis we administered Allopurinol mouthwash in 42 patients who had experienced oral mucositis during prior treatment with 5FU. In all patients significant reduction of oral toxicity was noticed as well as prolonged pain relief.

Authors+Show Affiliations

Second Department of Medical Oncology, Metaxa Cancer Hospital, Piraeus, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

1771297

Citation

Tsavaris, N B., et al. "Decreased Oral Toxicity With the Local Use of Allopurinol in Patients Who Received High Dose 5-fluorouracil." Selective Cancer Therapeutics, vol. 7, no. 3, 1991, pp. 113-7.
Tsavaris NB, Komitsopoulou P, Tzannou I, et al. Decreased oral toxicity with the local use of allopurinol in patients who received high dose 5-fluorouracil. Sel Cancer Ther. 1991;7(3):113-7.
Tsavaris, N. B., Komitsopoulou, P., Tzannou, I., Loucatou, P., Tsaroucha-Noutsou, A., Kilafis, G., & Kosmidis, P. (1991). Decreased oral toxicity with the local use of allopurinol in patients who received high dose 5-fluorouracil. Selective Cancer Therapeutics, 7(3), 113-7.
Tsavaris NB, et al. Decreased Oral Toxicity With the Local Use of Allopurinol in Patients Who Received High Dose 5-fluorouracil. Sel Cancer Ther. 1991;7(3):113-7. PubMed PMID: 1771297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased oral toxicity with the local use of allopurinol in patients who received high dose 5-fluorouracil. AU - Tsavaris,N B, AU - Komitsopoulou,P, AU - Tzannou,I, AU - Loucatou,P, AU - Tsaroucha-Noutsou,A, AU - Kilafis,G, AU - Kosmidis,P, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 113 EP - 7 JF - Selective cancer therapeutics JO - Sel Cancer Ther VL - 7 IS - 3 N2 - 5-Fluorouracil (5FU) is the most effective drug in gastrointestinal cancer. Mucositis and bone marrow toxicity are the two major limiting side effects. In our effort to reduce mucositis we administered Allopurinol mouthwash in 42 patients who had experienced oral mucositis during prior treatment with 5FU. In all patients significant reduction of oral toxicity was noticed as well as prolonged pain relief. SN - 1043-0733 UR - https://www.unboundmedicine.com/medline/citation/1771297/Decreased_oral_toxicity_with_the_local_use_of_allopurinol_in_patients_who_received_high_dose_5_fluorouracil_ L2 - https://www.lens.org/lens/search?q=citation_id:1771297 DB - PRIME DP - Unbound Medicine ER -