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Nail thickness measurements using optical coherence tomography and 20-MHz ultrasonography.
Br J Dermatol. 2007 Nov; 157(5):894-900.BJ

Abstract

BACKGROUND

Nail diseases are often troubling to the patient and may present a diagnostic challenge to the dermatologist. Biopsies from the nail may be required although often perceived uncomfortable by the patient and potentially scarring. Noninvasive technologies are therefore of particular interest in the study of nails. Optical coherence tomography (OCT) is an optical imaging modality which may provide improved data.

OBJECTIVES

This study evaluates nail morphology and thickness in OCT images in comparison with high-frequency ultrasound (HFUS) imaging of the nail.

METHODS

Ten healthy volunteers were recruited for imaging and nail measurements; OCT and HFUS images were compared qualitatively. Nail thickness measurements with four different techniques were compared: ultrasound, OCT, polarization-sensitive (PS) OCT and callipers. The OCT system was developed at Risoe National Laboratory, Denmark. A commercially available 20-MHz ultrasound system (Dermascan; Cortex Technology, Hadsund, Denmark) was used.

RESULTS

In standard OCT the nail plate appeared as a layered structure containing a varying number of horizontal homogeneous bands of varying intensity and thickness. PS-OCT images of the nail plate also showed a layered structure. The refractive index of the nail was 1.47 +/- 0.09. OCT and PS-OCT had low coefficients of variation, 6.31 and 6.53, respectively, compared with other methods: HFUS 12.70 and callipers 14.03.

CONCLUSION

PS-OCT has to our knowledge not been applied to OCT analysis of the nail, and offers some advantages in separation of the nail bed from the nail plate.

Authors+Show Affiliations

Department of Dermatology, Roskilde Hospital, Koegevej 7-13, DK-4000 Roskilde, Denmark. rsmmog@ra.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17714567

Citation

Mogensen, M, et al. "Nail Thickness Measurements Using Optical Coherence Tomography and 20-MHz Ultrasonography." The British Journal of Dermatology, vol. 157, no. 5, 2007, pp. 894-900.
Mogensen M, Thomsen JB, Skovgaard LT, et al. Nail thickness measurements using optical coherence tomography and 20-MHz ultrasonography. Br J Dermatol. 2007;157(5):894-900.
Mogensen, M., Thomsen, J. B., Skovgaard, L. T., & Jemec, G. B. (2007). Nail thickness measurements using optical coherence tomography and 20-MHz ultrasonography. The British Journal of Dermatology, 157(5), 894-900.
Mogensen M, et al. Nail Thickness Measurements Using Optical Coherence Tomography and 20-MHz Ultrasonography. Br J Dermatol. 2007;157(5):894-900. PubMed PMID: 17714567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nail thickness measurements using optical coherence tomography and 20-MHz ultrasonography. AU - Mogensen,M, AU - Thomsen,J B, AU - Skovgaard,L T, AU - Jemec,G B E, Y1 - 2007/08/21/ PY - 2007/8/24/pubmed PY - 2008/4/9/medline PY - 2007/8/24/entrez SP - 894 EP - 900 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 157 IS - 5 N2 - BACKGROUND: Nail diseases are often troubling to the patient and may present a diagnostic challenge to the dermatologist. Biopsies from the nail may be required although often perceived uncomfortable by the patient and potentially scarring. Noninvasive technologies are therefore of particular interest in the study of nails. Optical coherence tomography (OCT) is an optical imaging modality which may provide improved data. OBJECTIVES: This study evaluates nail morphology and thickness in OCT images in comparison with high-frequency ultrasound (HFUS) imaging of the nail. METHODS: Ten healthy volunteers were recruited for imaging and nail measurements; OCT and HFUS images were compared qualitatively. Nail thickness measurements with four different techniques were compared: ultrasound, OCT, polarization-sensitive (PS) OCT and callipers. The OCT system was developed at Risoe National Laboratory, Denmark. A commercially available 20-MHz ultrasound system (Dermascan; Cortex Technology, Hadsund, Denmark) was used. RESULTS: In standard OCT the nail plate appeared as a layered structure containing a varying number of horizontal homogeneous bands of varying intensity and thickness. PS-OCT images of the nail plate also showed a layered structure. The refractive index of the nail was 1.47 +/- 0.09. OCT and PS-OCT had low coefficients of variation, 6.31 and 6.53, respectively, compared with other methods: HFUS 12.70 and callipers 14.03. CONCLUSION: PS-OCT has to our knowledge not been applied to OCT analysis of the nail, and offers some advantages in separation of the nail bed from the nail plate. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17714567/Nail_thickness_measurements_using_optical_coherence_tomography_and_20_MHz_ultrasonography_ L2 - https://doi.org/10.1111/j.1365-2133.2007.08118.x DB - PRIME DP - Unbound Medicine ER -