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Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor.
J Psychopharmacol 2007; 21(8):826-32JP

Abstract

It has previously been postulated that the therapeutic effect of antidepressants, particularly selective serotonin re-uptake inhibitors (SSRIs), is mediated by a down-regulation of somatodendritic (presynaptic) 5-HT(1A) autoreceptors with chronic treatment. Animal studies have revealed that repeated administration of corticosteroids similarly down-regulate this receptor. However, it has previously been difficult to explore if this receptor is similarly modulated in man in vivo. The objective of this study was to explore the effect of repeated administration of cortisol to healthy volunteers utilising a novel putative index of somatodendritic 5-HT(1A) autoreceptor function. This method involves the administration of the 5-HT(1A) agonist buspirone and observing the subsequent negative shift in the frequency spectrum of the electroencephalogram (EEG). Healthy male volunteers were treated with cortisol 20 mg, or placebo, orally twice daily for 7 days in a double-blind random-order crossover study. After each treatment period volunteers were administered buspirone 30 mg orally prior to EEG recordings. Following a week's treatment with placebo, buspirone led to a negative shift in the EEG frequency spectrum as previously reported. However, following treatment with cortisol, the effect of buspirone was significantly attenuated. This is consistent with corticosteroids having a similar effect on somatodendritic 5-HT(1A) autoreceptors in man as seen in rodents.

Authors+Show Affiliations

Psychobiology Research Group, School of Neuroscience and Psychiatry, University of Newcastle, Newcastle upon Tyne, UK. r.h.mcallister-williams@ncl.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17715208

Citation

McAllister-Williams, R Hamish, et al. "Repeated Cortisol Administration Attenuates the EEG Response to Buspirone in Healthy Volunteers: Evidence for Desensitization of the 5-HT1A Autoreceptor." Journal of Psychopharmacology (Oxford, England), vol. 21, no. 8, 2007, pp. 826-32.
McAllister-Williams RH, Massey AE, Fairchild G. Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor. J Psychopharmacol (Oxford). 2007;21(8):826-32.
McAllister-Williams, R. H., Massey, A. E., & Fairchild, G. (2007). Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor. Journal of Psychopharmacology (Oxford, England), 21(8), pp. 826-32.
McAllister-Williams RH, Massey AE, Fairchild G. Repeated Cortisol Administration Attenuates the EEG Response to Buspirone in Healthy Volunteers: Evidence for Desensitization of the 5-HT1A Autoreceptor. J Psychopharmacol (Oxford). 2007;21(8):826-32. PubMed PMID: 17715208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor. AU - McAllister-Williams,R Hamish, AU - Massey,Anna E, AU - Fairchild,Graeme, Y1 - 2007/08/22/ PY - 2007/8/24/pubmed PY - 2008/1/30/medline PY - 2007/8/24/entrez SP - 826 EP - 32 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 21 IS - 8 N2 - It has previously been postulated that the therapeutic effect of antidepressants, particularly selective serotonin re-uptake inhibitors (SSRIs), is mediated by a down-regulation of somatodendritic (presynaptic) 5-HT(1A) autoreceptors with chronic treatment. Animal studies have revealed that repeated administration of corticosteroids similarly down-regulate this receptor. However, it has previously been difficult to explore if this receptor is similarly modulated in man in vivo. The objective of this study was to explore the effect of repeated administration of cortisol to healthy volunteers utilising a novel putative index of somatodendritic 5-HT(1A) autoreceptor function. This method involves the administration of the 5-HT(1A) agonist buspirone and observing the subsequent negative shift in the frequency spectrum of the electroencephalogram (EEG). Healthy male volunteers were treated with cortisol 20 mg, or placebo, orally twice daily for 7 days in a double-blind random-order crossover study. After each treatment period volunteers were administered buspirone 30 mg orally prior to EEG recordings. Following a week's treatment with placebo, buspirone led to a negative shift in the EEG frequency spectrum as previously reported. However, following treatment with cortisol, the effect of buspirone was significantly attenuated. This is consistent with corticosteroids having a similar effect on somatodendritic 5-HT(1A) autoreceptors in man as seen in rodents. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/17715208/Repeated_cortisol_administration_attenuates_the_EEG_response_to_buspirone_in_healthy_volunteers:_evidence_for_desensitization_of_the_5_HT1A_autoreceptor_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881107078292?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -