Abstract
BACKGROUND
Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin.
AIM
To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin.
DESIGN AND METHODS
Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6.
RESULTS
On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated.
CONCLUSIONS
Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.
Pub Type(s)
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
TY - JOUR
T1 - Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test.
AU - Ortonne,J-P,
AU - Queille-Roussel,C,
PY - 2007/10/11/pubmed
PY - 2008/4/5/medline
PY - 2007/10/11/entrez
SP - 19
EP - 25
JF - Journal of the European Academy of Dermatology and Venereology : JEADV
JO - J Eur Acad Dermatol Venereol
VL - 21 Suppl 2
N2 - BACKGROUND: Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin. AIM: To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin. DESIGN AND METHODS: Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6. RESULTS: On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated. CONCLUSIONS: Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.
SN - 0926-9959
UR - https://www.unboundmedicine.com/medline/citation/17716288/Evaluation_of_the_effect_of_Dardia_Lipo_Line_on_skin_inflammation_induced_by_surfactants_using_the_repeated_open_application_test_
L2 - https://doi.org/10.1111/j.1468-3083.2007.02383.x
DB - PRIME
DP - Unbound Medicine
ER -
