Tags

Type your tag names separated by a space and hit enter

Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test.
J Eur Acad Dermatol Venereol. 2007 Sep; 21 Suppl 2:19-25.JE

Abstract

BACKGROUND

Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin.

AIM

To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin.

DESIGN AND METHODS

Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6.

RESULTS

On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated.

CONCLUSIONS

Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.

Authors+Show Affiliations

Department of Dermatology, Hôpital l'Archet 2, Nice, France. ortonne@unice.frNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17716288

Citation

Ortonne, J-P, and C Queille-Roussel. "Evaluation of the Effect of Dardia Lipo Line On Skin Inflammation Induced By Surfactants Using the Repeated Open-application Test." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21 Suppl 2, 2007, pp. 19-25.
Ortonne JP, Queille-Roussel C. Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test. J Eur Acad Dermatol Venereol. 2007;21 Suppl 2:19-25.
Ortonne, J. P., & Queille-Roussel, C. (2007). Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test. Journal of the European Academy of Dermatology and Venereology : JEADV, 21 Suppl 2, 19-25.
Ortonne JP, Queille-Roussel C. Evaluation of the Effect of Dardia Lipo Line On Skin Inflammation Induced By Surfactants Using the Repeated Open-application Test. J Eur Acad Dermatol Venereol. 2007;21 Suppl 2:19-25. PubMed PMID: 17716288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test. AU - Ortonne,J-P, AU - Queille-Roussel,C, PY - 2007/10/11/pubmed PY - 2008/4/5/medline PY - 2007/10/11/entrez SP - 19 EP - 25 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 Suppl 2 N2 - BACKGROUND: Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin. AIM: To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin. DESIGN AND METHODS: Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6. RESULTS: On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated. CONCLUSIONS: Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17716288/Evaluation_of_the_effect_of_Dardia_Lipo_Line_on_skin_inflammation_induced_by_surfactants_using_the_repeated_open_application_test_ L2 - https://doi.org/10.1111/j.1468-3083.2007.02383.x DB - PRIME DP - Unbound Medicine ER -