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Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects.
J Gastroenterol Hepatol. 2007 Sep; 22(9):1443-9.JG

Abstract

BACKGROUND

Anti-inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti-inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan.

METHODS

The IL-10-1082 (A/G)/-819 (T/C)/-592 (A/C) polymorphisms were assessed in Helicobacter pylori-positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori-negative controls (n = 168) by allele specific primer-polymerase chain reaction methods.

RESULTS

The carriage of IL-10-592 C (age and sex-adjusted odds ratio [OR]: 1.851, 95% confidence interval [CI]: 1.018-3.380) and IL-10-819 C (adjusted OR: 1.868, 95%CI: 1.023-3.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The IL-10-1082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA/GCC haplotype of IL-10-1082/-819/-592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258-6.254) compared with presence of the ATA/ATA haplotype.

CONCLUSIONS

The IL-10-1082/-819/-592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti-inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development.

Authors+Show Affiliations

First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan. mitsu@hama-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17716348

Citation

Sugimoto, Mitsushige, et al. "Effects of Interleukin-10 Gene Polymorphism On the Development of Gastric Cancer and Peptic Ulcer in Japanese Subjects." Journal of Gastroenterology and Hepatology, vol. 22, no. 9, 2007, pp. 1443-9.
Sugimoto M, Furuta T, Shirai N, et al. Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol. 2007;22(9):1443-9.
Sugimoto, M., Furuta, T., Shirai, N., Nakamura, A., Kajimura, M., Sugimura, H., & Hishida, A. (2007). Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. Journal of Gastroenterology and Hepatology, 22(9), 1443-9.
Sugimoto M, et al. Effects of Interleukin-10 Gene Polymorphism On the Development of Gastric Cancer and Peptic Ulcer in Japanese Subjects. J Gastroenterol Hepatol. 2007;22(9):1443-9. PubMed PMID: 17716348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. AU - Sugimoto,Mitsushige, AU - Furuta,Takahisa, AU - Shirai,Naohito, AU - Nakamura,Akiko, AU - Kajimura,Masayoshi, AU - Sugimura,Haruhiko, AU - Hishida,Akira, PY - 2007/8/25/pubmed PY - 2008/3/13/medline PY - 2007/8/25/entrez SP - 1443 EP - 9 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 22 IS - 9 N2 - BACKGROUND: Anti-inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti-inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan. METHODS: The IL-10-1082 (A/G)/-819 (T/C)/-592 (A/C) polymorphisms were assessed in Helicobacter pylori-positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori-negative controls (n = 168) by allele specific primer-polymerase chain reaction methods. RESULTS: The carriage of IL-10-592 C (age and sex-adjusted odds ratio [OR]: 1.851, 95% confidence interval [CI]: 1.018-3.380) and IL-10-819 C (adjusted OR: 1.868, 95%CI: 1.023-3.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The IL-10-1082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA/GCC haplotype of IL-10-1082/-819/-592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258-6.254) compared with presence of the ATA/ATA haplotype. CONCLUSIONS: The IL-10-1082/-819/-592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti-inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17716348/Effects_of_interleukin_10_gene_polymorphism_on_the_development_of_gastric_cancer_and_peptic_ulcer_in_Japanese_subjects_ L2 - https://doi.org/10.1111/j.1440-1746.2006.04613.x DB - PRIME DP - Unbound Medicine ER -