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Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves.
Eur J Pharmacol. 2007 Dec 08; 576(1-3):180-8.EJ

Abstract

In this work, the anti-tumor properties of the volatile oil from Zanthoxylum rhoifolium Lam leaves and some terpenes (alpha-humulene, beta-caryophyllene, alpha-pinene and beta-pinene) were investigated in vitro and in vivo using the Ehrlich ascites tumor model. Treatment of Ehrlich ascites tumor-bearing mice with 20 mg/kg of the volatile oil and beta-caryophyllene for 4 days has significantly increased survival, whereas administration of alpha-humulene, alpha-pinene and beta-pinene were ineffective in affording protection. Volatile oil and beta-caryophyllene exhibited little direct activity against Ehrlich tumor cells in vitro, while alpha-humulene, alpha-pinene and beta-pinene did not such activity. Investigation of the effects of the volatile oil (and terpenes) treatment on total natural killer cells (NK cell) activity from tumor-bearing mice as a possible mechanism of these compounds in vivo revealed that volatile oil and beta-caryophyllene significantly improved NK cell cytotoxicity against YAC-1, a Moloney virus-induced mouse T-cell lymphoma of A/SN origin and Ehrlich ascites cells. As expected, tumor growth in non-treated mice markedly suppressed NK cell cytolysis while the volatile oil and beta-caryophyllene reversed this effect when mice were treated with 20-mg/kg dosages of these compounds for 4 days. Summing up, volatile oil exhibits anti-tumor efficacy and significative immunomodulatory action in vivo, which may be related to beta-caryophyllene associated to the synergism of other natural compounds presented in volatile oil from Z. rhoifolium Lam leaves.

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Authors+Show Affiliations

da Silva SL
Instituto de Ciências Exatas, Universidade Federal do Amazônas, UFAM, 69077-000, Manaus, AM, Brazil. biomol2@hotmail.com
Figueiredo PM
No affiliation info available
Yano T
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsCarcinoma, Ehrlich TumorCell Line, TumorCell SurvivalKiller Cells, NaturalMaleMiceMice, Inbred BALB COils, VolatilePlant LeavesRatsRats, Sprague-DawleyTerpenesTumor Cells, CulturedZanthoxylum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17716654

Citation

da Silva, Saulo L., et al. "Chemotherapeutic Potential of the Volatile Oils From Zanthoxylum Rhoifolium Lam Leaves." European Journal of Pharmacology, vol. 576, no. 1-3, 2007, pp. 180-8.
da Silva SL, Figueiredo PM, Yano T. Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves. Eur J Pharmacol. 2007;576(1-3):180-8.
da Silva, S. L., Figueiredo, P. M., & Yano, T. (2007). Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves. European Journal of Pharmacology, 576(1-3), 180-8.
da Silva SL, Figueiredo PM, Yano T. Chemotherapeutic Potential of the Volatile Oils From Zanthoxylum Rhoifolium Lam Leaves. Eur J Pharmacol. 2007 Dec 8;576(1-3):180-8. PubMed PMID: 17716654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves. AU - da Silva,Saulo L, AU - Figueiredo,Patrícia M S, AU - Yano,Tomomasa, Y1 - 2007/08/03/ PY - 2007/02/24/received PY - 2007/07/24/revised PY - 2007/07/26/accepted PY - 2007/8/25/pubmed PY - 2008/3/7/medline PY - 2007/8/25/entrez SP - 180 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 576 IS - 1-3 N2 - In this work, the anti-tumor properties of the volatile oil from Zanthoxylum rhoifolium Lam leaves and some terpenes (alpha-humulene, beta-caryophyllene, alpha-pinene and beta-pinene) were investigated in vitro and in vivo using the Ehrlich ascites tumor model. Treatment of Ehrlich ascites tumor-bearing mice with 20 mg/kg of the volatile oil and beta-caryophyllene for 4 days has significantly increased survival, whereas administration of alpha-humulene, alpha-pinene and beta-pinene were ineffective in affording protection. Volatile oil and beta-caryophyllene exhibited little direct activity against Ehrlich tumor cells in vitro, while alpha-humulene, alpha-pinene and beta-pinene did not such activity. Investigation of the effects of the volatile oil (and terpenes) treatment on total natural killer cells (NK cell) activity from tumor-bearing mice as a possible mechanism of these compounds in vivo revealed that volatile oil and beta-caryophyllene significantly improved NK cell cytotoxicity against YAC-1, a Moloney virus-induced mouse T-cell lymphoma of A/SN origin and Ehrlich ascites cells. As expected, tumor growth in non-treated mice markedly suppressed NK cell cytolysis while the volatile oil and beta-caryophyllene reversed this effect when mice were treated with 20-mg/kg dosages of these compounds for 4 days. Summing up, volatile oil exhibits anti-tumor efficacy and significative immunomodulatory action in vivo, which may be related to beta-caryophyllene associated to the synergism of other natural compounds presented in volatile oil from Z. rhoifolium Lam leaves. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17716654/Chemotherapeutic_potential_of_the_volatile_oils_from_Zanthoxylum_rhoifolium_Lam_leaves_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00859-X DB - PRIME DP - Unbound Medicine ER -