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Type 2 diabetes mellitus and the risk of open-angle glaucoma the Los Angeles Latino Eye Study.
Ophthalmology 2008; 115(2):227-232.e1O

Abstract

PURPOSE

To examine the relationship between type 2 diabetes mellitus (T2DM) and the risk of having open-angle glaucoma (OAG) in an adult Latino population.

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

Latinos 40 years and older (n = 5894) from 6 census tracts in Los Angeles, California.

METHODS

Participants from the Los Angeles Latino Eye Study (LALES), a large population-based study of self-identified adult Latinos, answered an interviewer-administered questionnaire and underwent a clinical and complete ocular examination, including visual field (VF) testing and stereo fundus photography. A participant was defined as having diabetes mellitus (DM) if she or he had a history of being treated for DM, the participant's glycosylated hemoglobin was measured at 7.0% or higher, or the participant had random blood glucose of 200 mg% or higher. Type 2 DM was defined if the participant was 30 years or older when diagnosed with DM. Open-angle glaucoma was defined as the presence of an open angle and a glaucomatous VF abnormality and/or evidence of glaucomatous optic disc damage in at least one eye. Logistic regression analysis was used to identify the risk of having OAG in persons with T2DM.

MAIN OUTCOME MEASURE

Prevalence of OAG.

RESULTS

Of the 5894 participants with complete data, 1157 (19.6%) had T2DM and 288 (4.9%) had OAG. The prevalence of OAG was 40% higher in participants with T2DM than in those without T2DM (age/gender/intraocular pressure-adjusted odds ratio, 1.4; 95% confidence interval, 1.03-1.8; P = 0.03). Trend analysis revealed that a longer duration of T2DM (stratified into 5-year increments) was associated with a higher prevalence of OAG (P<0.0001).

CONCLUSION

The presence of T2DM and a longer duration of T2DM were independently associated with a higher risk of having OAG in the LALES cohort. The high prevalences of T2DM and OAG and their association in this fastest growing segment of the United States population have significant implications for designing screening programs targeting Latinos.

Authors+Show Affiliations

Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17716734

Citation

Chopra, Vikas, et al. "Type 2 Diabetes Mellitus and the Risk of Open-angle Glaucoma the Los Angeles Latino Eye Study." Ophthalmology, vol. 115, no. 2, 2008, pp. 227-232.e1.
Chopra V, Varma R, Francis BA, et al. Type 2 diabetes mellitus and the risk of open-angle glaucoma the Los Angeles Latino Eye Study. Ophthalmology. 2008;115(2):227-232.e1.
Chopra, V., Varma, R., Francis, B. A., Wu, J., Torres, M., & Azen, S. P. (2008). Type 2 diabetes mellitus and the risk of open-angle glaucoma the Los Angeles Latino Eye Study. Ophthalmology, 115(2), pp. 227-232.e1.
Chopra V, et al. Type 2 Diabetes Mellitus and the Risk of Open-angle Glaucoma the Los Angeles Latino Eye Study. Ophthalmology. 2008;115(2):227-232.e1. PubMed PMID: 17716734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes mellitus and the risk of open-angle glaucoma the Los Angeles Latino Eye Study. AU - Chopra,Vikas, AU - Varma,Rohit, AU - Francis,Brian A, AU - Wu,Joanne, AU - Torres,Mina, AU - Azen,Stanley P, AU - ,, Y1 - 2007/08/22/ PY - 2006/10/03/received PY - 2007/04/26/revised PY - 2007/04/30/accepted PY - 2007/8/25/pubmed PY - 2008/2/12/medline PY - 2007/8/25/entrez SP - 227 EP - 232.e1 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 2 N2 - PURPOSE: To examine the relationship between type 2 diabetes mellitus (T2DM) and the risk of having open-angle glaucoma (OAG) in an adult Latino population. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Latinos 40 years and older (n = 5894) from 6 census tracts in Los Angeles, California. METHODS: Participants from the Los Angeles Latino Eye Study (LALES), a large population-based study of self-identified adult Latinos, answered an interviewer-administered questionnaire and underwent a clinical and complete ocular examination, including visual field (VF) testing and stereo fundus photography. A participant was defined as having diabetes mellitus (DM) if she or he had a history of being treated for DM, the participant's glycosylated hemoglobin was measured at 7.0% or higher, or the participant had random blood glucose of 200 mg% or higher. Type 2 DM was defined if the participant was 30 years or older when diagnosed with DM. Open-angle glaucoma was defined as the presence of an open angle and a glaucomatous VF abnormality and/or evidence of glaucomatous optic disc damage in at least one eye. Logistic regression analysis was used to identify the risk of having OAG in persons with T2DM. MAIN OUTCOME MEASURE: Prevalence of OAG. RESULTS: Of the 5894 participants with complete data, 1157 (19.6%) had T2DM and 288 (4.9%) had OAG. The prevalence of OAG was 40% higher in participants with T2DM than in those without T2DM (age/gender/intraocular pressure-adjusted odds ratio, 1.4; 95% confidence interval, 1.03-1.8; P = 0.03). Trend analysis revealed that a longer duration of T2DM (stratified into 5-year increments) was associated with a higher prevalence of OAG (P<0.0001). CONCLUSION: The presence of T2DM and a longer duration of T2DM were independently associated with a higher risk of having OAG in the LALES cohort. The high prevalences of T2DM and OAG and their association in this fastest growing segment of the United States population have significant implications for designing screening programs targeting Latinos. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17716734/Type_2_diabetes_mellitus_and_the_risk_of_open_angle_glaucoma_the_Los_Angeles_Latino_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00504-0 DB - PRIME DP - Unbound Medicine ER -