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Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome.
Brain Behav Immun. 2008 Feb; 22(2):177-84.BB

Abstract

BACKGROUND AND OBJECTIVE

Women with polycystic ovary syndrome (PCOS) present with multiple risk factors for cardiovascular diseases at a young age, including obesity and chronic low-grade inflammation. Since depression is common in PCOS, this study aimed to address whether depression correlates with indices of chronic low-grade inflammation beyond the association with obesity.

METHODS

Serum concentrations of IL-6, the stimulated production of IFN-gamma, TNF-alpha, IL-2, IL-4, IL-5, and IL-10, leukocyte numbers, and hsCRP were analyzed in 57 PCOS patients and 28 healthy women, together with clinical parameters, including body mass index (BMI), testosterone, and insulin resistance (HOMA-IR), and psychological parameters, including Beck Depression Inventory (BDI) and health-related quality-of-life (SF-36) scores.

RESULTS

PCOS patients demonstrated significantly increased hsCRP, IL-6, and leukocyte numbers. Group differences in IL-6 and leukocyte numbers, but not hsCRP, disappeared after controlling for BMI. The stimulated production of IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-5 was significantly decreased, irrespective of BMI. In PCOS, hsCRP, IL-6, and leukocyte numbers were correlated with BMI, HDL, diastolic blood pressure, and with insulin resistance. On the other hand, no correlations were found with depression scores or with PCOS-specific endocrine abnormalities. In regression models, BMI was a significant predictor of the key immune markers, and explained a large amount of variance, whereas BDI was not included in either model.

CONCLUSIONS

These data confirm that obesity plays a pivotal role in inflammatory processes relevant to cardiovascular risk in women with PCOS. However, even lean PCOS patients may display subtle alterations in specific aspects of immunity. Our findings did not support a correlation of depression with chronic low-grade inflammation in PCOS.

Authors+Show Affiliations

Department of Medical Psychology & Behavioral Immunobiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17716857

Citation

Benson, S, et al. "Obesity, Depression, and Chronic Low-grade Inflammation in Women With Polycystic Ovary Syndrome." Brain, Behavior, and Immunity, vol. 22, no. 2, 2008, pp. 177-84.
Benson S, Janssen OE, Hahn S, et al. Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome. Brain Behav Immun. 2008;22(2):177-84.
Benson, S., Janssen, O. E., Hahn, S., Tan, S., Dietz, T., Mann, K., Pleger, K., Schedlowski, M., Arck, P. C., & Elsenbruch, S. (2008). Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome. Brain, Behavior, and Immunity, 22(2), 177-84.
Benson S, et al. Obesity, Depression, and Chronic Low-grade Inflammation in Women With Polycystic Ovary Syndrome. Brain Behav Immun. 2008;22(2):177-84. PubMed PMID: 17716857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome. AU - Benson,S, AU - Janssen,O E, AU - Hahn,S, AU - Tan,S, AU - Dietz,T, AU - Mann,K, AU - Pleger,K, AU - Schedlowski,M, AU - Arck,P C, AU - Elsenbruch,S, Y1 - 2007/08/22/ PY - 2007/05/04/received PY - 2007/06/28/revised PY - 2007/07/13/accepted PY - 2007/8/25/pubmed PY - 2008/2/6/medline PY - 2007/8/25/entrez SP - 177 EP - 84 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 22 IS - 2 N2 - BACKGROUND AND OBJECTIVE: Women with polycystic ovary syndrome (PCOS) present with multiple risk factors for cardiovascular diseases at a young age, including obesity and chronic low-grade inflammation. Since depression is common in PCOS, this study aimed to address whether depression correlates with indices of chronic low-grade inflammation beyond the association with obesity. METHODS: Serum concentrations of IL-6, the stimulated production of IFN-gamma, TNF-alpha, IL-2, IL-4, IL-5, and IL-10, leukocyte numbers, and hsCRP were analyzed in 57 PCOS patients and 28 healthy women, together with clinical parameters, including body mass index (BMI), testosterone, and insulin resistance (HOMA-IR), and psychological parameters, including Beck Depression Inventory (BDI) and health-related quality-of-life (SF-36) scores. RESULTS: PCOS patients demonstrated significantly increased hsCRP, IL-6, and leukocyte numbers. Group differences in IL-6 and leukocyte numbers, but not hsCRP, disappeared after controlling for BMI. The stimulated production of IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-5 was significantly decreased, irrespective of BMI. In PCOS, hsCRP, IL-6, and leukocyte numbers were correlated with BMI, HDL, diastolic blood pressure, and with insulin resistance. On the other hand, no correlations were found with depression scores or with PCOS-specific endocrine abnormalities. In regression models, BMI was a significant predictor of the key immune markers, and explained a large amount of variance, whereas BDI was not included in either model. CONCLUSIONS: These data confirm that obesity plays a pivotal role in inflammatory processes relevant to cardiovascular risk in women with PCOS. However, even lean PCOS patients may display subtle alterations in specific aspects of immunity. Our findings did not support a correlation of depression with chronic low-grade inflammation in PCOS. SN - 1090-2139 UR - https://www.unboundmedicine.com/medline/citation/17716857/Obesity_depression_and_chronic_low_grade_inflammation_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(07)00166-3 DB - PRIME DP - Unbound Medicine ER -