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Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats.
Acta Biochim Pol. 2007; 54(3):641-6.AB

Abstract

This study compared the ability of daidzein, a soy isoflavone, with that of 17beta-estradiol to prevent bone loss in cadmium (Cd)-exposed ovariectomized (OVX) rats during growth. Four week-old female Wistar rats were randomly assigned to five treatment groups of 9 rats each, either (1) sham-operated (SH); (2) OVX and placed on experimental diets (OVX); (3) OVX fed 50 ppm of CdCl2 (OVX-Cd); (4) OVX fed 50 ppm of CdCl2 and 10 microg of daidzein per kg of body mass (OVX-CD-D); or (5) OVX fed 50 ppm of CdCl2 and 10 microg of estrogen per kg of body mass (OVX-CD-E). All rats were given free access to AIN-76 modified diet and drinking water, with or without Cd, for 8 weeks. The OVX groups gained more (P < 0.05) body mass than the SH group. Femoral mass was increased by feeding daidzein and estradiol, whereas femoral length was not (P > 0.05) significantly different among groups. Femoral breaking force was not significantly different among groups, however, femoral BMD was significantly lower in OVX-Cd than in the SH and OVX groups. Morphologically proliferative cartilage and hypertrophic cells in femur showed normal distribution in OVX-Cd-D and OVX-Cd-E groups unlike those in OVX-Cd group. These findings suggest that Cd-OVX-induced osteopenia or osteoporosis probably results from an increase in bone turnover.

Authors+Show Affiliations

Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, South Korea. aesonom@hanyang.ac.krNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17717607

Citation

Om, Ae-Son, and Jae-Young Shim. "Effect of Daidzein, a Soy Isoflavone, On Bone Metabolism in Cd-treated Ovariectomized Rats." Acta Biochimica Polonica, vol. 54, no. 3, 2007, pp. 641-6.
Om AS, Shim JY. Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats. Acta Biochim Pol. 2007;54(3):641-6.
Om, A. S., & Shim, J. Y. (2007). Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats. Acta Biochimica Polonica, 54(3), 641-6.
Om AS, Shim JY. Effect of Daidzein, a Soy Isoflavone, On Bone Metabolism in Cd-treated Ovariectomized Rats. Acta Biochim Pol. 2007;54(3):641-6. PubMed PMID: 17717607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats. AU - Om,Ae-Son, AU - Shim,Jae-Young, Y1 - 2007/08/24/ PY - 2006/08/08/received PY - 2006/11/28/revised PY - 2007/08/01/accepted PY - 2007/8/25/pubmed PY - 2008/7/12/medline PY - 2007/8/25/entrez SP - 641 EP - 6 JF - Acta biochimica Polonica JO - Acta Biochim. Pol. VL - 54 IS - 3 N2 - This study compared the ability of daidzein, a soy isoflavone, with that of 17beta-estradiol to prevent bone loss in cadmium (Cd)-exposed ovariectomized (OVX) rats during growth. Four week-old female Wistar rats were randomly assigned to five treatment groups of 9 rats each, either (1) sham-operated (SH); (2) OVX and placed on experimental diets (OVX); (3) OVX fed 50 ppm of CdCl2 (OVX-Cd); (4) OVX fed 50 ppm of CdCl2 and 10 microg of daidzein per kg of body mass (OVX-CD-D); or (5) OVX fed 50 ppm of CdCl2 and 10 microg of estrogen per kg of body mass (OVX-CD-E). All rats were given free access to AIN-76 modified diet and drinking water, with or without Cd, for 8 weeks. The OVX groups gained more (P < 0.05) body mass than the SH group. Femoral mass was increased by feeding daidzein and estradiol, whereas femoral length was not (P > 0.05) significantly different among groups. Femoral breaking force was not significantly different among groups, however, femoral BMD was significantly lower in OVX-Cd than in the SH and OVX groups. Morphologically proliferative cartilage and hypertrophic cells in femur showed normal distribution in OVX-Cd-D and OVX-Cd-E groups unlike those in OVX-Cd group. These findings suggest that Cd-OVX-induced osteopenia or osteoporosis probably results from an increase in bone turnover. SN - 0001-527X UR - https://www.unboundmedicine.com/medline/citation/17717607/Effect_of_daidzein_a_soy_isoflavone_on_bone_metabolism_in_Cd_treated_ovariectomized_rats_ L2 - http://www.actabp.pl/pdf/3_2007/641.pdf DB - PRIME DP - Unbound Medicine ER -