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Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology.
J Vet Med A Physiol Pathol Clin Med. 2007 Sep; 54(7):346-51.JV

Abstract

The carpal joints are common sites of traumatic arthritis and osteoarthritis (OA) in athletic horses. The pro-inflammatory cytokines interleukin (IL)-6 and tumour necrosis factor (TNF) may be of great importance in the development of intra-articular lesions. The aim of the present study was to investigate possible associations between synovial fluid levels of bioactive IL-6 and TNF and different types of joint lesions seen in traumatic arthritis and OA. Synovial fluid was collected from horses with carpal lameness immediately before arthroscopic surgery. Articular cartilage, synovial membranes and intra-articular ligaments were assessed macroscopically at arthroscopy. Synovial fluid levels of IL-6 and TNF were determined by bioassays, and the cytokine levels between different grades of morphologic changes in each type of assessed tissue were compared. The highest levels of IL-6 were detected in joints with chip fractures. All joints with chip fractures also showed some degree of synovitis. Tumour necrosis factor bioactivity was low and not associated with any joint lesion. Hence, TNF is not useful as a biomarker indicating a specific joint lesion in equine traumatic arthritis or OA. We conclude that a dramatic increase of IL-6 in synovial fluid indicates the presence of osteochondral fragmentation, although low or undetectable levels of IL-6 do not exclude chip fractures. The role of IL-6 in the disease process of osteochondral fragmentation needs further investigation.

Authors+Show Affiliations

Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden. cecilia.ley@bvf.slu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17718806

Citation

Ley, C, et al. "Interleukin-6 and Tumour Necrosis Factor in Synovial Fluid From Horses With Carpal Joint Pathology." Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, vol. 54, no. 7, 2007, pp. 346-51.
Ley C, Ekman S, Elmén A, et al. Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology. J Vet Med A Physiol Pathol Clin Med. 2007;54(7):346-51.
Ley, C., Ekman, S., Elmén, A., Nilsson, G., & Eloranta, M. L. (2007). Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, 54(7), 346-51.
Ley C, et al. Interleukin-6 and Tumour Necrosis Factor in Synovial Fluid From Horses With Carpal Joint Pathology. J Vet Med A Physiol Pathol Clin Med. 2007;54(7):346-51. PubMed PMID: 17718806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology. AU - Ley,C, AU - Ekman,S, AU - Elmén,A, AU - Nilsson,G, AU - Eloranta,M-L, PY - 2007/8/28/pubmed PY - 2007/11/9/medline PY - 2007/8/28/entrez SP - 346 EP - 51 JF - Journal of veterinary medicine. A, Physiology, pathology, clinical medicine JO - J Vet Med A Physiol Pathol Clin Med VL - 54 IS - 7 N2 - The carpal joints are common sites of traumatic arthritis and osteoarthritis (OA) in athletic horses. The pro-inflammatory cytokines interleukin (IL)-6 and tumour necrosis factor (TNF) may be of great importance in the development of intra-articular lesions. The aim of the present study was to investigate possible associations between synovial fluid levels of bioactive IL-6 and TNF and different types of joint lesions seen in traumatic arthritis and OA. Synovial fluid was collected from horses with carpal lameness immediately before arthroscopic surgery. Articular cartilage, synovial membranes and intra-articular ligaments were assessed macroscopically at arthroscopy. Synovial fluid levels of IL-6 and TNF were determined by bioassays, and the cytokine levels between different grades of morphologic changes in each type of assessed tissue were compared. The highest levels of IL-6 were detected in joints with chip fractures. All joints with chip fractures also showed some degree of synovitis. Tumour necrosis factor bioactivity was low and not associated with any joint lesion. Hence, TNF is not useful as a biomarker indicating a specific joint lesion in equine traumatic arthritis or OA. We conclude that a dramatic increase of IL-6 in synovial fluid indicates the presence of osteochondral fragmentation, although low or undetectable levels of IL-6 do not exclude chip fractures. The role of IL-6 in the disease process of osteochondral fragmentation needs further investigation. SN - 0931-184X UR - https://www.unboundmedicine.com/medline/citation/17718806/Interleukin_6_and_tumour_necrosis_factor_in_synovial_fluid_from_horses_with_carpal_joint_pathology_ L2 - https://doi.org/10.1111/j.1439-0442.2007.00956.x DB - PRIME DP - Unbound Medicine ER -