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The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects.
Clin Nutr. 2007 Dec; 26(6):792-8.CN

Abstract

BACKGROUND & AIMS

The purpose of this study was to evaluate the effect of low-fat products enriched with plant sterols in addition to a National Cholesterol Education Program step 1 diet on serum lipids and lipoproteins.

METHODS

This study was a double-blind, randomised, placebo-controlled cross-over design with a run-in period and 2 intervention periods, each lasting 4 weeks. A total of 46 mildly hypercholesterolemic subjects (age 50.6+/-9.8) completed the trial. The study products consisted of 20 g low-fat margarine (35% fat) and 250 ml low-fat milk (0.7% fat), in total delivering 2.3g plant sterols/d.

RESULTS

Serum total and low-density lipoprotein cholesterol were significantly reduced by 5.5% (p<0.001, 95% CI: 2.5; 8.3) and 7.7% (p=0.001, 95% CI: 3.4; 11.9), respectively, by plant sterol-enriched products compared to placebo. Serum apolipoprotein B was significantly reduced by 4.6% (p<0.05, 95% CI: 1.7; 7.5), and apolipoprotein B/apolipoprotein A-I by 3.4% (p<0.05, 95% CI: 0.1; 6.6) after plant sterol intake compared to the placebo supplement.

CONCLUSIONS

A combination of low-fat margarine and milk enriched with plant sterols significantly reduced low-density lipoprotein cholesterol, apolipoprotein B and the ratio of apolipoprotein B to apolipoprotein A-I in mildly hypercholesterolemic subjects, but had no effect on C-reactive protein and lipoprotein (a) concentrations.

SPONSORSHIP

Unilever Denmark A/S.

Authors+Show Affiliations

Department of Cardiology, Center for Cardiovascular Research, Arhus University Hospitals, Aalborg Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17719702

Citation

Madsen, Martin B., et al. "The Effect of a Combination of Plant Sterol-enriched Foods in Mildly Hypercholesterolemic Subjects." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 6, 2007, pp. 792-8.
Madsen MB, Jensen AM, Schmidt EB. The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. Clin Nutr. 2007;26(6):792-8.
Madsen, M. B., Jensen, A. M., & Schmidt, E. B. (2007). The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. Clinical Nutrition (Edinburgh, Scotland), 26(6), 792-8.
Madsen MB, Jensen AM, Schmidt EB. The Effect of a Combination of Plant Sterol-enriched Foods in Mildly Hypercholesterolemic Subjects. Clin Nutr. 2007;26(6):792-8. PubMed PMID: 17719702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. AU - Madsen,Martin B, AU - Jensen,Anne-Mette, AU - Schmidt,Erik B, Y1 - 2007/08/24/ PY - 2006/12/05/received PY - 2007/04/13/revised PY - 2007/05/24/accepted PY - 2007/8/28/pubmed PY - 2008/3/1/medline PY - 2007/8/28/entrez SP - 792 EP - 8 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 6 N2 - BACKGROUND & AIMS: The purpose of this study was to evaluate the effect of low-fat products enriched with plant sterols in addition to a National Cholesterol Education Program step 1 diet on serum lipids and lipoproteins. METHODS: This study was a double-blind, randomised, placebo-controlled cross-over design with a run-in period and 2 intervention periods, each lasting 4 weeks. A total of 46 mildly hypercholesterolemic subjects (age 50.6+/-9.8) completed the trial. The study products consisted of 20 g low-fat margarine (35% fat) and 250 ml low-fat milk (0.7% fat), in total delivering 2.3g plant sterols/d. RESULTS: Serum total and low-density lipoprotein cholesterol were significantly reduced by 5.5% (p<0.001, 95% CI: 2.5; 8.3) and 7.7% (p=0.001, 95% CI: 3.4; 11.9), respectively, by plant sterol-enriched products compared to placebo. Serum apolipoprotein B was significantly reduced by 4.6% (p<0.05, 95% CI: 1.7; 7.5), and apolipoprotein B/apolipoprotein A-I by 3.4% (p<0.05, 95% CI: 0.1; 6.6) after plant sterol intake compared to the placebo supplement. CONCLUSIONS: A combination of low-fat margarine and milk enriched with plant sterols significantly reduced low-density lipoprotein cholesterol, apolipoprotein B and the ratio of apolipoprotein B to apolipoprotein A-I in mildly hypercholesterolemic subjects, but had no effect on C-reactive protein and lipoprotein (a) concentrations. SPONSORSHIP: Unilever Denmark A/S. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/17719702/The_effect_of_a_combination_of_plant_sterol_enriched_foods_in_mildly_hypercholesterolemic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(07)00096-9 DB - PRIME DP - Unbound Medicine ER -