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The biology of a chronic obstructive pulmonary disease exacerbation.
Clin Chest Med. 2007 Sep; 28(3):525-36, v.CC

Abstract

Much of the morbidity and mortality in chronic obstructive pulmonary disease relates to symptomatic deteriorations in respiratory health termed exacerbations. Exacerbations also are associated with changes in lung function and both airway and systemic inflammation. The most common causes of exacerbation are micro-organisms: respiratory viruses such as rhinovirus, and various bacterial species. This article reviews and discusses current understanding of the biology of exacerbations, considering the definition, epidemiology, etiology, and the nature and evolution of the changes in symptoms, lung function, and inflammation that characterize these important events.

Authors+Show Affiliations

Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital, London, NW3 2PF, UK.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17720041

Citation

Hurst, John R., and Jadwiga A. Wedzicha. "The Biology of a Chronic Obstructive Pulmonary Disease Exacerbation." Clinics in Chest Medicine, vol. 28, no. 3, 2007, pp. 525-36, v.
Hurst JR, Wedzicha JA. The biology of a chronic obstructive pulmonary disease exacerbation. Clin Chest Med. 2007;28(3):525-36, v.
Hurst, J. R., & Wedzicha, J. A. (2007). The biology of a chronic obstructive pulmonary disease exacerbation. Clinics in Chest Medicine, 28(3), 525-36, v.
Hurst JR, Wedzicha JA. The Biology of a Chronic Obstructive Pulmonary Disease Exacerbation. Clin Chest Med. 2007;28(3):525-36, v. PubMed PMID: 17720041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The biology of a chronic obstructive pulmonary disease exacerbation. AU - Hurst,John R, AU - Wedzicha,Jadwiga A, PY - 2007/8/28/pubmed PY - 2007/12/19/medline PY - 2007/8/28/entrez SP - 525-36, v JF - Clinics in chest medicine JO - Clin. Chest Med. VL - 28 IS - 3 N2 - Much of the morbidity and mortality in chronic obstructive pulmonary disease relates to symptomatic deteriorations in respiratory health termed exacerbations. Exacerbations also are associated with changes in lung function and both airway and systemic inflammation. The most common causes of exacerbation are micro-organisms: respiratory viruses such as rhinovirus, and various bacterial species. This article reviews and discusses current understanding of the biology of exacerbations, considering the definition, epidemiology, etiology, and the nature and evolution of the changes in symptoms, lung function, and inflammation that characterize these important events. SN - 0272-5231 UR - https://www.unboundmedicine.com/medline/citation/17720041/The_biology_of_a_chronic_obstructive_pulmonary_disease_exacerbation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-5231(07)00056-1 DB - PRIME DP - Unbound Medicine ER -