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On the relationship between lens stiffness and accommodative amplitude.
Exp Eye Res. 2007 Nov; 85(5):602-7.EE

Abstract

The purpose of this study was to investigate the relationship between the stiffness of the material comprising the lens and the loss of accommodative amplitude with age. We used a validated mechanical model to determine the changes in the shape of the lens during accommodation and disaccommodation. The relative contribution of lens stiffness to loss of accommodative amplitude with age was determined by varying lens stiffness in the model. The changes in lens stiffness with age were based on the results of two recently published studies. In the first study we showed that lens stiffness increases exponentially with age, and in the second study we showed that there is a considerable stiffness gradient within the lens that changes with age. The results of both studies were incorporated in the mechanical model. The model showed that it is not the increasing stiffness of the lens with age, but rather the changing stiffness gradient that influences accommodative amplitude. The results show that the changing stiffness gradient in the lens may be responsible for almost the entire loss of accommodation with age.

Authors+Show Affiliations

AMO Groningen, van Swietenlaan 5, 9728 NX Groningen, The Netherlands. henk.weeber@amo-inc.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17720158

Citation

Weeber, Henk A., and Rob G L. van der Heijde. "On the Relationship Between Lens Stiffness and Accommodative Amplitude." Experimental Eye Research, vol. 85, no. 5, 2007, pp. 602-7.
Weeber HA, van der Heijde RG. On the relationship between lens stiffness and accommodative amplitude. Exp Eye Res. 2007;85(5):602-7.
Weeber, H. A., & van der Heijde, R. G. (2007). On the relationship between lens stiffness and accommodative amplitude. Experimental Eye Research, 85(5), 602-7.
Weeber HA, van der Heijde RG. On the Relationship Between Lens Stiffness and Accommodative Amplitude. Exp Eye Res. 2007;85(5):602-7. PubMed PMID: 17720158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the relationship between lens stiffness and accommodative amplitude. AU - Weeber,Henk A, AU - van der Heijde,Rob G L, Y1 - 2007/07/25/ PY - 2007/02/15/received PY - 2007/06/22/revised PY - 2007/07/14/accepted PY - 2007/8/28/pubmed PY - 2008/2/22/medline PY - 2007/8/28/entrez SP - 602 EP - 7 JF - Experimental eye research JO - Exp. Eye Res. VL - 85 IS - 5 N2 - The purpose of this study was to investigate the relationship between the stiffness of the material comprising the lens and the loss of accommodative amplitude with age. We used a validated mechanical model to determine the changes in the shape of the lens during accommodation and disaccommodation. The relative contribution of lens stiffness to loss of accommodative amplitude with age was determined by varying lens stiffness in the model. The changes in lens stiffness with age were based on the results of two recently published studies. In the first study we showed that lens stiffness increases exponentially with age, and in the second study we showed that there is a considerable stiffness gradient within the lens that changes with age. The results of both studies were incorporated in the mechanical model. The model showed that it is not the increasing stiffness of the lens with age, but rather the changing stiffness gradient that influences accommodative amplitude. The results show that the changing stiffness gradient in the lens may be responsible for almost the entire loss of accommodation with age. SN - 0014-4835 UR - https://www.unboundmedicine.com/medline/citation/17720158/On_the_relationship_between_lens_stiffness_and_accommodative_amplitude_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4835(07)00202-3 DB - PRIME DP - Unbound Medicine ER -