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Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis.
Toxicology. 2007 Oct 30; 240(1-2):60-9.T

Abstract

OBJECTIVE

Role of chemokines in the pathogenesis of pulmonary fibrosis (PF) due to sulfur mustard (SM) gas inhalation.

PATIENTS

18 veterans with SM gas-induced PF, 15 patients with IPF and 18 normal as controls.

INTERVENTION

Chest roentgenograms, PFTs, the percentage DLCO, high-resolution CT scans of the chest, and analyses of BAL fluids for chemokines (MCP-1, MIP-1 alpha, and MIP-1 beta) were performed in all cases.

RESULTS

There were significant differences in chemokines (MCP-1, MIP-1 alpha, and MIP-1 beta) levels of BAL fluid between patients with PF and healthy controls (p<0.0006). MCP-1 and MIP-1 alpha levels in BAL fluid correlate only with the percentage and the absolute number lymphocytes of the BAL fluid in patients with PF due to SM gas inhalation (p=0.0006/p=0.03; p=0.04/p=0.02; respectively). The BAL fluid level of MIP-alpha in SM gas-induced PF was significantly correlated with the number of lymphocytes (r=-0.56, p=0.01), neutrophils (r=-0.50, p=0.03) and eosinophils (r=-0.49, p=0.03). A significant negative correlation was observed between the percentage of Dlco and MCP-1 and MIP-1 alpha levels in BAL fluid in patients with PF (r=-0.65, p=0.003; r=-0.48, p=0.04; respectively).

CONCLUSION

Neutrophils alveolitis, presence of eosinophils, and higher concentrations of interleukin MCP-1, MIP-1 alpha, and MIP-1 beta in BAL fluid are associated with the development of fibrosis in SM victims.

Authors+Show Affiliations

Department of Internal Medicine, Section of Pulmonary Diseases, Shiraz University of Medical Sciences, Shiraz, Iran. lungdep@pearl.sums.ac.irNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17720292

Citation

Emad, Ali, and Vahid Emad. "Elevated Levels of MCP-1, MIP-alpha and MIP-1 Beta in the Bronchoalveolar Lavage (BAL) Fluid of Patients With Mustard Gas-induced Pulmonary Fibrosis." Toxicology, vol. 240, no. 1-2, 2007, pp. 60-9.
Emad A, Emad V. Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. Toxicology. 2007;240(1-2):60-9.
Emad, A., & Emad, V. (2007). Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. Toxicology, 240(1-2), 60-9.
Emad A, Emad V. Elevated Levels of MCP-1, MIP-alpha and MIP-1 Beta in the Bronchoalveolar Lavage (BAL) Fluid of Patients With Mustard Gas-induced Pulmonary Fibrosis. Toxicology. 2007 Oct 30;240(1-2):60-9. PubMed PMID: 17720292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. AU - Emad,Ali, AU - Emad,Vahid, Y1 - 2007/08/01/ PY - 2007/06/13/received PY - 2007/07/18/revised PY - 2007/07/19/accepted PY - 2007/8/28/pubmed PY - 2007/12/6/medline PY - 2007/8/28/entrez SP - 60 EP - 9 JF - Toxicology JO - Toxicology VL - 240 IS - 1-2 N2 - OBJECTIVE: Role of chemokines in the pathogenesis of pulmonary fibrosis (PF) due to sulfur mustard (SM) gas inhalation. PATIENTS: 18 veterans with SM gas-induced PF, 15 patients with IPF and 18 normal as controls. INTERVENTION: Chest roentgenograms, PFTs, the percentage DLCO, high-resolution CT scans of the chest, and analyses of BAL fluids for chemokines (MCP-1, MIP-1 alpha, and MIP-1 beta) were performed in all cases. RESULTS: There were significant differences in chemokines (MCP-1, MIP-1 alpha, and MIP-1 beta) levels of BAL fluid between patients with PF and healthy controls (p<0.0006). MCP-1 and MIP-1 alpha levels in BAL fluid correlate only with the percentage and the absolute number lymphocytes of the BAL fluid in patients with PF due to SM gas inhalation (p=0.0006/p=0.03; p=0.04/p=0.02; respectively). The BAL fluid level of MIP-alpha in SM gas-induced PF was significantly correlated with the number of lymphocytes (r=-0.56, p=0.01), neutrophils (r=-0.50, p=0.03) and eosinophils (r=-0.49, p=0.03). A significant negative correlation was observed between the percentage of Dlco and MCP-1 and MIP-1 alpha levels in BAL fluid in patients with PF (r=-0.65, p=0.003; r=-0.48, p=0.04; respectively). CONCLUSION: Neutrophils alveolitis, presence of eosinophils, and higher concentrations of interleukin MCP-1, MIP-1 alpha, and MIP-1 beta in BAL fluid are associated with the development of fibrosis in SM victims. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17720292/Elevated_levels_of_MCP_1_MIP_alpha_and_MIP_1_beta_in_the_bronchoalveolar_lavage__BAL__fluid_of_patients_with_mustard_gas_induced_pulmonary_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00482-9 DB - PRIME DP - Unbound Medicine ER -