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The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat.
Neurosci Lett. 2007 Sep 20; 425(1):12-7.NL

Abstract

Kainate is an excitatory amino acid receptor agonist with a structure similar to the amino acid L-proline. Our previous studies demonstrated that microinjections of L-proline into the ventrolateral medulla (VLM) of the rat induce a mapped pattern of blood pressure responses distinct from L-glutamate, and the depressor response to L-proline in the caudal VLM (CVLM) is abolished by the kainate/AMPA receptor antagonist CNQX. The present study investigated whether kainate produces the L-proline-mapped pattern of responses in the VLM, compared with the pattern by AMPA. Kainate is known to activate AMPA receptors at higher concentrations. Therefore, responses to kainate were investigated at a low concentration. Microinjections of AMPA or NMDA showed the pattern of the L-glutamate-type; a pressor response in the rostral VLM and caudal pressor area (CPA) and a depressor response in the CVLM. Microinjections of kainate showed depressor responses in the CVLM but minor pressor responses in the rostral VLM, suggesting the same responses to L-proline. However, the response sites in the CPA did not enable us to clearly determine the L-proline-type. Further trials at sites defined by a pressor response to L-glutamate in the CPA, successive injections of L-proline and kainate produced no response, indicating that L-glutamate responding neurons in the CPA are not sensitive to L-proline and kainate. These results suggest that kainate stimulation in the VLM produces a mapped pattern of ABP responses similar to the mapped pattern with L-proline. Kainate receptors could therefore be involved in the depressor response to L-proline in the medulla.

Authors+Show Affiliations

Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. yumitake@hiroshima-u.ac.jp

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17720316

Citation

Takemoto, Yumi. "The Mapped Pattern of Kainate On Blood Pressure Responses Is Similar to That of L-proline in the Ventrolateral Medulla of the Rat." Neuroscience Letters, vol. 425, no. 1, 2007, pp. 12-7.
Takemoto Y. The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat. Neurosci Lett. 2007;425(1):12-7.
Takemoto, Y. (2007). The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat. Neuroscience Letters, 425(1), 12-7.
Takemoto Y. The Mapped Pattern of Kainate On Blood Pressure Responses Is Similar to That of L-proline in the Ventrolateral Medulla of the Rat. Neurosci Lett. 2007 Sep 20;425(1):12-7. PubMed PMID: 17720316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat. A1 - Takemoto,Yumi, Y1 - 2007/08/06/ PY - 2007/05/15/received PY - 2007/08/01/revised PY - 2007/08/02/accepted PY - 2007/8/28/pubmed PY - 2008/1/10/medline PY - 2007/8/28/entrez SP - 12 EP - 7 JF - Neuroscience letters JO - Neurosci. Lett. VL - 425 IS - 1 N2 - Kainate is an excitatory amino acid receptor agonist with a structure similar to the amino acid L-proline. Our previous studies demonstrated that microinjections of L-proline into the ventrolateral medulla (VLM) of the rat induce a mapped pattern of blood pressure responses distinct from L-glutamate, and the depressor response to L-proline in the caudal VLM (CVLM) is abolished by the kainate/AMPA receptor antagonist CNQX. The present study investigated whether kainate produces the L-proline-mapped pattern of responses in the VLM, compared with the pattern by AMPA. Kainate is known to activate AMPA receptors at higher concentrations. Therefore, responses to kainate were investigated at a low concentration. Microinjections of AMPA or NMDA showed the pattern of the L-glutamate-type; a pressor response in the rostral VLM and caudal pressor area (CPA) and a depressor response in the CVLM. Microinjections of kainate showed depressor responses in the CVLM but minor pressor responses in the rostral VLM, suggesting the same responses to L-proline. However, the response sites in the CPA did not enable us to clearly determine the L-proline-type. Further trials at sites defined by a pressor response to L-glutamate in the CPA, successive injections of L-proline and kainate produced no response, indicating that L-glutamate responding neurons in the CPA are not sensitive to L-proline and kainate. These results suggest that kainate stimulation in the VLM produces a mapped pattern of ABP responses similar to the mapped pattern with L-proline. Kainate receptors could therefore be involved in the depressor response to L-proline in the medulla. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17720316/The_mapped_pattern_of_kainate_on_blood_pressure_responses_is_similar_to_that_of_L_proline_in_the_ventrolateral_medulla_of_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00837-3 DB - PRIME DP - Unbound Medicine ER -