Tags

Type your tag names separated by a space and hit enter

Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies.
Acta Diabetol. 2007 Sep; 44(3):106-13.AD

Abstract

Obesity is well known to be a contributory risk factor for several disease states, including diabetes mellitus. Paucity of data on maternal-foetal status of essential trace elements in obese diabetic pregnancies prompted us to undertake this study. Maternal venous and umbilical arterial and venous blood samples were collected from obese gestational diabetic patients (Body Mass Index (BMI) >30) and control obese pregnant women (BMI>30) at time of spontaneous delivery or caesarean sections and concentrations of essential trace elements such as Cu, Fe, Mo, Se and Zn were determined in various samples by atomic absorption spectrophotometry. Activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPX) and total antioxidant (TAO) in maternal and umbilical blood were assessed using appropriate reagent kits. Maternal-foetal disposition and exchange parameters of elements studied were assessed using established criteria. Concentrations of Cu, Fe, Mo, Se and Zn in serum of control obese pregnant women (n=10) averaged 2404, 2663, 11.0, 89.0 and 666 microg/l respectively, while in the obese diabetic group (n=11), the corresponding values averaged 2441, 2580, 13.3, 85.1 and 610 microg/l respectively. Activities of antioxidant enzymes such as SOD, GPX and TAO were not significantly different in maternal veins of control and diabetic groups. Varying differences were noted in the case of antioxidant enzyme activities in umbilical blood samples of control and study groups. We conclude that obesity is not associated with significant alterations in antioxidant enzyme status in gestational diabetes and only with relatively minor alterations in status of some essential trace elements.

Authors+Show Affiliations

Department of Obstetrics & Gynecology Faculty of Medicine, University of Kuwait, P.O. Box 24923, Safat, 13110, Kuwait. rania@hsc.edu.kwNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17721748

Citation

Al-Saleh, E, et al. "Maternal-foetal Status of Copper, Iron, Molybdenum, Selenium and Zinc in Obese Gestational Diabetic Pregnancies." Acta Diabetologica, vol. 44, no. 3, 2007, pp. 106-13.
Al-Saleh E, Nandakumaran M, Al-Rashdan I, et al. Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. Acta Diabetol. 2007;44(3):106-13.
Al-Saleh, E., Nandakumaran, M., Al-Rashdan, I., Al-Harmi, J., & Al-Shammari, M. (2007). Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. Acta Diabetologica, 44(3), 106-13.
Al-Saleh E, et al. Maternal-foetal Status of Copper, Iron, Molybdenum, Selenium and Zinc in Obese Gestational Diabetic Pregnancies. Acta Diabetol. 2007;44(3):106-13. PubMed PMID: 17721748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. AU - Al-Saleh,E, AU - Nandakumaran,M, AU - Al-Rashdan,I, AU - Al-Harmi,J, AU - Al-Shammari,M, Y1 - 2007/08/26/ PY - 2006/07/05/received PY - 2007/03/29/accepted PY - 2007/8/28/pubmed PY - 2007/12/6/medline PY - 2007/8/28/entrez SP - 106 EP - 13 JF - Acta diabetologica JO - Acta Diabetol VL - 44 IS - 3 N2 - Obesity is well known to be a contributory risk factor for several disease states, including diabetes mellitus. Paucity of data on maternal-foetal status of essential trace elements in obese diabetic pregnancies prompted us to undertake this study. Maternal venous and umbilical arterial and venous blood samples were collected from obese gestational diabetic patients (Body Mass Index (BMI) >30) and control obese pregnant women (BMI>30) at time of spontaneous delivery or caesarean sections and concentrations of essential trace elements such as Cu, Fe, Mo, Se and Zn were determined in various samples by atomic absorption spectrophotometry. Activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPX) and total antioxidant (TAO) in maternal and umbilical blood were assessed using appropriate reagent kits. Maternal-foetal disposition and exchange parameters of elements studied were assessed using established criteria. Concentrations of Cu, Fe, Mo, Se and Zn in serum of control obese pregnant women (n=10) averaged 2404, 2663, 11.0, 89.0 and 666 microg/l respectively, while in the obese diabetic group (n=11), the corresponding values averaged 2441, 2580, 13.3, 85.1 and 610 microg/l respectively. Activities of antioxidant enzymes such as SOD, GPX and TAO were not significantly different in maternal veins of control and diabetic groups. Varying differences were noted in the case of antioxidant enzyme activities in umbilical blood samples of control and study groups. We conclude that obesity is not associated with significant alterations in antioxidant enzyme status in gestational diabetes and only with relatively minor alterations in status of some essential trace elements. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/17721748/Maternal_foetal_status_of_copper_iron_molybdenum_selenium_and_zinc_in_obese_gestational_diabetic_pregnancies_ L2 - https://dx.doi.org/10.1007/s00592-007-0250-x DB - PRIME DP - Unbound Medicine ER -