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Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias.
Neurochem Res. 2008 Mar; 33(3):450-8.NR

Abstract

It has been reported that oxidative stress may play a role in the pathogenesis of dementia of the Alzheimer type (AD) and the cerebral ischemia which causes vascular dementia (VD). We measured malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities in blood samples from patients with AD and VD and in healthy non-demented controls (CTR) which similar ages to the patients, in order to evaluate the degree of oxidative stress in patients with AD and VD. A sample of 150 subjects consisting of 50 patients with AD; 50 patients with VD and 50 CTR, aged from 65 to 85 years on, was analyzed. Most of the changes observed were in SOD activity and MDA levels. Catalase activity were least affected. Significant differences were observed in SOD and GR activity between males and females in CRT and in patients with AD, but not in VD. We have found a decrease in antioxidant enzymes activities (SOD, CAT, GPx and GR) in patients with AD and VD and significant differences were observed between CRT and AD patients for ages from 65 to 74, 75 to 84 and from 85 years to 94 years in SOD activity and MDA levels (P < 0.001). MDA levels increase with age in VD, AD and CTR. No significant variation with respect to sex were detected, but significant variations in MDA levels were detected between CRT and patients with VD and AD (P < 0.001). We conclude that oxidative stress plays an important role in the brain damage for both AD and VD, being observed higher levels of oxidative stress for AD that for VD.

Authors+Show Affiliations

Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu, 9, Madrid 28040, Spain. acasado@cib.csic.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17721818

Citation

Casado, Angela, et al. "Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias." Neurochemical Research, vol. 33, no. 3, 2008, pp. 450-8.
Casado A, Encarnación López-Fernández M, Concepción Casado M, et al. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem Res. 2008;33(3):450-8.
Casado, A., Encarnación López-Fernández, M., Concepción Casado, M., & de La Torre, R. (2008). Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochemical Research, 33(3), 450-8.
Casado A, et al. Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias. Neurochem Res. 2008;33(3):450-8. PubMed PMID: 17721818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. AU - Casado,Angela, AU - Encarnación López-Fernández,M, AU - Concepción Casado,M, AU - de La Torre,Rosario, Y1 - 2007/08/25/ PY - 2007/06/04/received PY - 2007/07/20/accepted PY - 2007/8/28/pubmed PY - 2008/5/7/medline PY - 2007/8/28/entrez SP - 450 EP - 8 JF - Neurochemical research JO - Neurochem Res VL - 33 IS - 3 N2 - It has been reported that oxidative stress may play a role in the pathogenesis of dementia of the Alzheimer type (AD) and the cerebral ischemia which causes vascular dementia (VD). We measured malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities in blood samples from patients with AD and VD and in healthy non-demented controls (CTR) which similar ages to the patients, in order to evaluate the degree of oxidative stress in patients with AD and VD. A sample of 150 subjects consisting of 50 patients with AD; 50 patients with VD and 50 CTR, aged from 65 to 85 years on, was analyzed. Most of the changes observed were in SOD activity and MDA levels. Catalase activity were least affected. Significant differences were observed in SOD and GR activity between males and females in CRT and in patients with AD, but not in VD. We have found a decrease in antioxidant enzymes activities (SOD, CAT, GPx and GR) in patients with AD and VD and significant differences were observed between CRT and AD patients for ages from 65 to 74, 75 to 84 and from 85 years to 94 years in SOD activity and MDA levels (P < 0.001). MDA levels increase with age in VD, AD and CTR. No significant variation with respect to sex were detected, but significant variations in MDA levels were detected between CRT and patients with VD and AD (P < 0.001). We conclude that oxidative stress plays an important role in the brain damage for both AD and VD, being observed higher levels of oxidative stress for AD that for VD. SN - 0364-3190 UR - https://www.unboundmedicine.com/medline/citation/17721818/Lipid_peroxidation_and_antioxidant_enzyme_activities_in_vascular_and_Alzheimer_dementias_ L2 - https://doi.org/10.1007/s11064-007-9453-3 DB - PRIME DP - Unbound Medicine ER -