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Work-related physical activity and the risk of dementia and Alzheimer's disease.

Abstract

BACKGROUND

Leisure-time physical activity has been related with a reduced risk of dementia and Alzheimer's disease (AD). The effects of occupational and commuting physical activity (physical activity at work and on the way to work) on cognitive health are still unclear. This study aimed to clarify the association between work-related physical activity and dementia/AD.

METHODS

Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 individuals (73%) aged 65 to 79 years participated in the re-examination in 1998.

RESULTS

Neither occupational [Odds Ratio (OR) 1.45; 95% Confidence Intervals (CI) 0.66-3.17] nor commuting physical activity (OR 0.46; 95% CI 0.10-2.17) were associated with the risk of dementia or AD after adjustments for age, sex, education, follow-up time, locomotor symptoms, main occupation during life, income at midlife, leisure-time physical activity, other subtype of work-related physical activity, ApoE genotype, vascular disorders and the smoking status. There were also no interactions between work-related physical activity and the ApoE epsilon4 genotype, leisure-time physical activity or sex.

CONCLUSIONS

In this study, work-related physical activity was not found to be sufficient to protect against dementia and AD later in life. The lack of effect might be partly due to a residual confounding. Nevertheless, physical activity during leisure-time may be beneficial even for people who are physically active at work or when commuting.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden. suvi.rovio@ki.se

    , , , , , ,

    Source

    MeSH

    Aged
    Alzheimer Disease
    Apolipoprotein E4
    Cerebrovascular Disorders
    Dementia
    Female
    Follow-Up Studies
    Genotype
    Health Surveys
    Humans
    Leisure Activities
    Male
    Motor Activity
    Odds Ratio
    Risk
    Sex Factors
    Smoking
    Work

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17721898

    Citation

    Rovio, Suvi, et al. "Work-related Physical Activity and the Risk of Dementia and Alzheimer's Disease." International Journal of Geriatric Psychiatry, vol. 22, no. 9, 2007, pp. 874-82.
    Rovio S, Kåreholt I, Viitanen M, et al. Work-related physical activity and the risk of dementia and Alzheimer's disease. Int J Geriatr Psychiatry. 2007;22(9):874-82.
    Rovio, S., Kåreholt, I., Viitanen, M., Winblad, B., Tuomilehto, J., Soininen, H., ... Kivipelto, M. (2007). Work-related physical activity and the risk of dementia and Alzheimer's disease. International Journal of Geriatric Psychiatry, 22(9), pp. 874-82.
    Rovio S, et al. Work-related Physical Activity and the Risk of Dementia and Alzheimer's Disease. Int J Geriatr Psychiatry. 2007;22(9):874-82. PubMed PMID: 17721898.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Work-related physical activity and the risk of dementia and Alzheimer's disease. AU - Rovio,Suvi, AU - Kåreholt,Ingemar, AU - Viitanen,Matti, AU - Winblad,Bengt, AU - Tuomilehto,Jaakko, AU - Soininen,Hilkka, AU - Nissinen,Aulikki, AU - Kivipelto,Miia, PY - 2007/8/28/pubmed PY - 2008/5/2/medline PY - 2007/8/28/entrez SP - 874 EP - 82 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 22 IS - 9 N2 - BACKGROUND: Leisure-time physical activity has been related with a reduced risk of dementia and Alzheimer's disease (AD). The effects of occupational and commuting physical activity (physical activity at work and on the way to work) on cognitive health are still unclear. This study aimed to clarify the association between work-related physical activity and dementia/AD. METHODS: Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 individuals (73%) aged 65 to 79 years participated in the re-examination in 1998. RESULTS: Neither occupational [Odds Ratio (OR) 1.45; 95% Confidence Intervals (CI) 0.66-3.17] nor commuting physical activity (OR 0.46; 95% CI 0.10-2.17) were associated with the risk of dementia or AD after adjustments for age, sex, education, follow-up time, locomotor symptoms, main occupation during life, income at midlife, leisure-time physical activity, other subtype of work-related physical activity, ApoE genotype, vascular disorders and the smoking status. There were also no interactions between work-related physical activity and the ApoE epsilon4 genotype, leisure-time physical activity or sex. CONCLUSIONS: In this study, work-related physical activity was not found to be sufficient to protect against dementia and AD later in life. The lack of effect might be partly due to a residual confounding. Nevertheless, physical activity during leisure-time may be beneficial even for people who are physically active at work or when commuting. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/17721898/Work_related_physical_activity_and_the_risk_of_dementia_and_Alzheimer's_disease_ L2 - https://doi.org/10.1002/gps.1755 DB - PRIME DP - Unbound Medicine ER -