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The spread of avian influenza H5N1 virus; a pandemic threat to mankind.
J Med Assoc Thai. 2006 Sep; 89 Suppl 3:S218-33.JM

Abstract

Influenza A H5N1 virus infection presents a major public health problem in Asian and Eurasian countries. The World Health organization has voiced their concerns about a potential pandemic with the imminent threat to humankind. In 1997, an outbreak of highly pathogenic H5N1 virus emerged and caused severe systemic disease among poultry and humans in Hong Kong. This article reviews the magnitude of the 2004-2006 outbreaks in various countries and highlights the highly pathogenic avian influenza (HPAI) subtype H5N1 virus as the cause of a major epidemic with potentially vast repercussions on economics, public health and society at large. Not only has this avian influenza (AI) virus infected poultry but has also proven highly pathogenic and fatal to mammalian species including humans and felines. The present review draws a comprehensive picture encompassing epidemiology, inter-species transmission and genetic characterization of this highly virulent virus. Moreover, laboratory diagnostic techniques, vaccination strategies and antiviral therapies aimed at outbreak control and management are also discussed.

Authors+Show Affiliations

Chutinimitkul S
Center of Excellence in Viral Hepatitis Research, Department ofPediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Payungporn S
No affiliation info available
Chieochansin T
No affiliation info available
Suwannakarn K
No affiliation info available
Theamboonlers A
No affiliation info available
Poovorawan Y
No affiliation info available

MeSH

Amino Acid SequenceAnimalsBirdsCatsCommunicable Disease ControlDisease OutbreaksDisease ReservoirsDisease Transmission, InfectiousDisease VectorsGlobal HealthHumansInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesInfluenza in BirdsInfluenza, HumanOrthomyxoviridae InfectionsPhylogenyZoonoses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17722309

Citation

Chutinimitkul, Salin, et al. "The Spread of Avian Influenza H5N1 Virus; a Pandemic Threat to Mankind." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 89 Suppl 3, 2006, pp. S218-33.
Chutinimitkul S, Payungporn S, Chieochansin T, et al. The spread of avian influenza H5N1 virus; a pandemic threat to mankind. J Med Assoc Thai. 2006;89 Suppl 3:S218-33.
Chutinimitkul, S., Payungporn, S., Chieochansin, T., Suwannakarn, K., Theamboonlers, A., & Poovorawan, Y. (2006). The spread of avian influenza H5N1 virus; a pandemic threat to mankind. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 89 Suppl 3, S218-33.
Chutinimitkul S, et al. The Spread of Avian Influenza H5N1 Virus; a Pandemic Threat to Mankind. J Med Assoc Thai. 2006;89 Suppl 3:S218-33. PubMed PMID: 17722309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The spread of avian influenza H5N1 virus; a pandemic threat to mankind. AU - Chutinimitkul,Salin, AU - Payungporn,Sunchai, AU - Chieochansin,Thaweesak, AU - Suwannakarn,Kamol, AU - Theamboonlers,Apiradee, AU - Poovorawan,Yong, PY - 2007/8/28/pubmed PY - 2007/9/28/medline PY - 2007/8/28/entrez SP - S218 EP - 33 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 89 Suppl 3 N2 - Influenza A H5N1 virus infection presents a major public health problem in Asian and Eurasian countries. The World Health organization has voiced their concerns about a potential pandemic with the imminent threat to humankind. In 1997, an outbreak of highly pathogenic H5N1 virus emerged and caused severe systemic disease among poultry and humans in Hong Kong. This article reviews the magnitude of the 2004-2006 outbreaks in various countries and highlights the highly pathogenic avian influenza (HPAI) subtype H5N1 virus as the cause of a major epidemic with potentially vast repercussions on economics, public health and society at large. Not only has this avian influenza (AI) virus infected poultry but has also proven highly pathogenic and fatal to mammalian species including humans and felines. The present review draws a comprehensive picture encompassing epidemiology, inter-species transmission and genetic characterization of this highly virulent virus. Moreover, laboratory diagnostic techniques, vaccination strategies and antiviral therapies aimed at outbreak control and management are also discussed. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/17722309/The_spread_of_avian_influenza_H5N1_virus DB - PRIME DP - Unbound Medicine ER -