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Hyperuricemia and metabolic syndrome in Taiwanese children.
Asia Pac J Clin Nutr 2007; 16 Suppl 2:594-600AP

Abstract

Metabolic fitness in childhood is of increasing concern in transitional and advanced economies as the metabolic syndrome (MS) is recognized more often in this age group. As the MS appears, so also does hyperuricemia. Studies in Taiwan have identified both indigenous and Chinese with high prevalence of hyperuricemia. Data (1227 boys and 1057 girls, aged 6-12) from the Nutrition and Health Survey in Taiwan Elementary School Children (NAHSIT Children 2001-2002) were used to appraise the association between uric acid (UA) and MS in children. Mean serum urate increases by age, ranging from 5.69 mg/dL to 7.11 mg/dL for boys and 5.61 mg/dL to 6.13 md/dL for girls. Boys have higher UA concentrations (6.07 mg/dL vs. 5.74 mg/dL) and hyperuricemia (UA > or = 7 mg/dL) rate (26.5% vs. 18.8%) than girls. Children of Mountain areas have higher rates of hyperuricemia (boys: 39.2%, girls: 30.1%). 5.56% of boys and 6.39% of girls were classified as having the MS by ATP III criteria. Serum urate was closely correlated with the MS parameters, and waist circumference (WC) in particular (r=0.387). WC alone accounted for 18% of variance of serum urate concentration. Both serum urate and hyperuricemia are significant risk factors for the MS (serum urate in mg/dL, OR: 1.54, 95% CI: 1.36-1.74; hyperuricemia, OR: 3.73, 95% CI: 2.47-5.62). Adjustment for age and region accentuate these relationships. Not only abdominal fatness, but also uric acid status, or both together may be of interest to public health workers and clinicians in regard to the transitional health problem of MS.

Authors+Show Affiliations

School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC. mmsl@ndmctsgh.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17724000

Citation

Lee, Meei-Shyuan, et al. "Hyperuricemia and Metabolic Syndrome in Taiwanese Children." Asia Pacific Journal of Clinical Nutrition, vol. 16 Suppl 2, 2007, pp. 594-600.
Lee MS, Wahlqvist ML, Yu HL, et al. Hyperuricemia and metabolic syndrome in Taiwanese children. Asia Pac J Clin Nutr. 2007;16 Suppl 2:594-600.
Lee, M. S., Wahlqvist, M. L., Yu, H. L., & Pan, W. H. (2007). Hyperuricemia and metabolic syndrome in Taiwanese children. Asia Pacific Journal of Clinical Nutrition, 16 Suppl 2, pp. 594-600.
Lee MS, et al. Hyperuricemia and Metabolic Syndrome in Taiwanese Children. Asia Pac J Clin Nutr. 2007;16 Suppl 2:594-600. PubMed PMID: 17724000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperuricemia and metabolic syndrome in Taiwanese children. AU - Lee,Meei-Shyuan, AU - Wahlqvist,Mark L, AU - Yu,Hsiao-Li, AU - Pan,Wen-Harn, PY - 2007/10/4/pubmed PY - 2007/10/24/medline PY - 2007/10/4/entrez SP - 594 EP - 600 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 16 Suppl 2 N2 - Metabolic fitness in childhood is of increasing concern in transitional and advanced economies as the metabolic syndrome (MS) is recognized more often in this age group. As the MS appears, so also does hyperuricemia. Studies in Taiwan have identified both indigenous and Chinese with high prevalence of hyperuricemia. Data (1227 boys and 1057 girls, aged 6-12) from the Nutrition and Health Survey in Taiwan Elementary School Children (NAHSIT Children 2001-2002) were used to appraise the association between uric acid (UA) and MS in children. Mean serum urate increases by age, ranging from 5.69 mg/dL to 7.11 mg/dL for boys and 5.61 mg/dL to 6.13 md/dL for girls. Boys have higher UA concentrations (6.07 mg/dL vs. 5.74 mg/dL) and hyperuricemia (UA > or = 7 mg/dL) rate (26.5% vs. 18.8%) than girls. Children of Mountain areas have higher rates of hyperuricemia (boys: 39.2%, girls: 30.1%). 5.56% of boys and 6.39% of girls were classified as having the MS by ATP III criteria. Serum urate was closely correlated with the MS parameters, and waist circumference (WC) in particular (r=0.387). WC alone accounted for 18% of variance of serum urate concentration. Both serum urate and hyperuricemia are significant risk factors for the MS (serum urate in mg/dL, OR: 1.54, 95% CI: 1.36-1.74; hyperuricemia, OR: 3.73, 95% CI: 2.47-5.62). Adjustment for age and region accentuate these relationships. Not only abdominal fatness, but also uric acid status, or both together may be of interest to public health workers and clinicians in regard to the transitional health problem of MS. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/17724000/Hyperuricemia_and_metabolic_syndrome_in_Taiwanese_children_ L2 - http://apjcn.nhri.org.tw/server/APJCN/16 Suppl 2//594.pdf DB - PRIME DP - Unbound Medicine ER -