Tags

Type your tag names separated by a space and hit enter

Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark.
J Pharm Pharmacol. 2007 Aug; 59(8):1151-8.JP

Abstract

We have evaluated the anti-inflammatory and analgesic properties of the leaves (LCE) and stem bark (BCE) crude extracts of Zanthoxylum riedelianum (Rutaceae). Different fractions of the stem bark extract (hexane, BCEH; dichloromethane, BCED; ethyl acetate, BCEE; and lyophilized aqueous residual, BCEW) were also investigated. We studied the effects of the extracts and fractions using the rat paw oedema test induced by carrageenan, dextran, histamine or nystatin; the mouse abdominal constriction test; the mouse hot-plate test (only for LCE and BCE); and the mouse formalin test. Both extracts and all BCE fractions displayed anti-inflammatory activity in the carrageenan-induced oedema model, but not for dextran, histamine or nystatin. Considering the analgesic models, both extracts showed antinociceptive activity, but BCE was more active than LCE in models of central pain. All BCE fractions showed significant inhibition in the abdominal constriction test and in both phases of the formalin test. When BCED was submitted to phytochemical procedures it led to the isolation of six lignans (sesamin, methylpluviatolide, dimethylmatairesinol, piperitol-4(')-O-(gamma),(gamma)-dimethylallyl ether, kaerophyllin and hinokinin), and a triterpene (lupeol). Inhibition of cyclooxygenase and its metabolites may have been involved in the mechanism of action of this plant, considering previous studies reporting the anti-inflammatory and analgesic activity for the identified lignans, as well as anti-inflammatory activity for lupeol.

Authors+Show Affiliations

Laboratório de Farmacognosia de Produtos Naturais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17725859

Citation

Lima, Leonardo Mandalho, et al. "Anti-inflammatory and Analgesic Activities of the Ethanolic Extracts From Zanthoxylum Riedelianum (Rutaceae) Leaves and Stem Bark." The Journal of Pharmacy and Pharmacology, vol. 59, no. 8, 2007, pp. 1151-8.
Lima LM, Perazzo FF, Tavares Carvalho JC, et al. Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. J Pharm Pharmacol. 2007;59(8):1151-8.
Lima, L. M., Perazzo, F. F., Tavares Carvalho, J. C., & Bastos, J. K. (2007). Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. The Journal of Pharmacy and Pharmacology, 59(8), 1151-8.
Lima LM, et al. Anti-inflammatory and Analgesic Activities of the Ethanolic Extracts From Zanthoxylum Riedelianum (Rutaceae) Leaves and Stem Bark. J Pharm Pharmacol. 2007;59(8):1151-8. PubMed PMID: 17725859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. AU - Lima,Leonardo Mandalho, AU - Perazzo,Fábio Ferreira, AU - Tavares Carvalho,José Carlos, AU - Bastos,Jairo Kenupp, PY - 2007/8/30/pubmed PY - 2007/10/20/medline PY - 2007/8/30/entrez SP - 1151 EP - 8 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 59 IS - 8 N2 - We have evaluated the anti-inflammatory and analgesic properties of the leaves (LCE) and stem bark (BCE) crude extracts of Zanthoxylum riedelianum (Rutaceae). Different fractions of the stem bark extract (hexane, BCEH; dichloromethane, BCED; ethyl acetate, BCEE; and lyophilized aqueous residual, BCEW) were also investigated. We studied the effects of the extracts and fractions using the rat paw oedema test induced by carrageenan, dextran, histamine or nystatin; the mouse abdominal constriction test; the mouse hot-plate test (only for LCE and BCE); and the mouse formalin test. Both extracts and all BCE fractions displayed anti-inflammatory activity in the carrageenan-induced oedema model, but not for dextran, histamine or nystatin. Considering the analgesic models, both extracts showed antinociceptive activity, but BCE was more active than LCE in models of central pain. All BCE fractions showed significant inhibition in the abdominal constriction test and in both phases of the formalin test. When BCED was submitted to phytochemical procedures it led to the isolation of six lignans (sesamin, methylpluviatolide, dimethylmatairesinol, piperitol-4(')-O-(gamma),(gamma)-dimethylallyl ether, kaerophyllin and hinokinin), and a triterpene (lupeol). Inhibition of cyclooxygenase and its metabolites may have been involved in the mechanism of action of this plant, considering previous studies reporting the anti-inflammatory and analgesic activity for the identified lignans, as well as anti-inflammatory activity for lupeol. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/17725859/Anti_inflammatory_and_analgesic_activities_of_the_ethanolic_extracts_from_Zanthoxylum_riedelianum__Rutaceae__leaves_and_stem_bark_ L2 - https://doi.org/10.1211/jpp.59.8.0014 DB - PRIME DP - Unbound Medicine ER -