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Changes in the immune system after moderate beer consumption.
Ann Nutr Metab. 2007; 51(4):359-66.AN

Abstract

BACKGROUND/AIM

Epidemiological studies have suggested that moderate alcohol consumption is associated with lower morbidity. However, intervention studies are needed to elucidate mechanisms involved. This study was aimed to determine the effects of moderate beer consumption on the immune function of healthy adults, taking into account gender differences.

METHODS

After a 30-day alcohol abstinence period, 57 healthy volunteers consumed a moderate intake of beer (330 ml for women and 660 ml for men) for 30 days. Total leukocyte and lymphocyte counts; absolute values of T-lymphocyte CD3+, CD4+, and CD8+ subsets; delayed-hypersensitivity skin response (DHSR); absolute values of B lymphocytes (CD19+) and serum immunoglobulin concentrations (IgG, IgA, and IgM); and cytokine production (IL-2, IL-4, IL-6, IL-10, IFN-gamma, and TNF-alpha) were evaluated following the abstinence and alcohol consumption periods.

RESULTS

After moderate beer consumption CD3+ cells increased only in women (p < 0.05). IgG, IgM, and IgA concentrations, as well as IL-2, IL-4, IL-10, and IFN-gamma cytokine production increased while IFN-gamma/IL-10 ratio decreased in both men and women (p < 0.05). The rest of the immunological parameters analyzed remained unchanged.

CONCLUSION

Moderate beer consumption produced an immunomodulatory effect in a healthy adult Spanish population; this effect appears to be more relevant in women than in men.

Authors+Show Affiliations

Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Consejo Superior de Investigaciones Científicas, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17726314

Citation

Romeo, Javier, et al. "Changes in the Immune System After Moderate Beer Consumption." Annals of Nutrition & Metabolism, vol. 51, no. 4, 2007, pp. 359-66.
Romeo J, Wärnberg J, Nova E, et al. Changes in the immune system after moderate beer consumption. Ann Nutr Metab. 2007;51(4):359-66.
Romeo, J., Wärnberg, J., Nova, E., Díaz, L. E., González-Gross, M., & Marcos, A. (2007). Changes in the immune system after moderate beer consumption. Annals of Nutrition & Metabolism, 51(4), 359-66.
Romeo J, et al. Changes in the Immune System After Moderate Beer Consumption. Ann Nutr Metab. 2007;51(4):359-66. PubMed PMID: 17726314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in the immune system after moderate beer consumption. AU - Romeo,Javier, AU - Wärnberg,Julia, AU - Nova,Esther, AU - Díaz,Ligia E, AU - González-Gross,Marcela, AU - Marcos,Ascensión, Y1 - 2007/08/28/ PY - 2006/01/20/received PY - 2007/01/10/accepted PY - 2007/8/30/pubmed PY - 2007/10/13/medline PY - 2007/8/30/entrez SP - 359 EP - 66 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 51 IS - 4 N2 - BACKGROUND/AIM: Epidemiological studies have suggested that moderate alcohol consumption is associated with lower morbidity. However, intervention studies are needed to elucidate mechanisms involved. This study was aimed to determine the effects of moderate beer consumption on the immune function of healthy adults, taking into account gender differences. METHODS: After a 30-day alcohol abstinence period, 57 healthy volunteers consumed a moderate intake of beer (330 ml for women and 660 ml for men) for 30 days. Total leukocyte and lymphocyte counts; absolute values of T-lymphocyte CD3+, CD4+, and CD8+ subsets; delayed-hypersensitivity skin response (DHSR); absolute values of B lymphocytes (CD19+) and serum immunoglobulin concentrations (IgG, IgA, and IgM); and cytokine production (IL-2, IL-4, IL-6, IL-10, IFN-gamma, and TNF-alpha) were evaluated following the abstinence and alcohol consumption periods. RESULTS: After moderate beer consumption CD3+ cells increased only in women (p < 0.05). IgG, IgM, and IgA concentrations, as well as IL-2, IL-4, IL-10, and IFN-gamma cytokine production increased while IFN-gamma/IL-10 ratio decreased in both men and women (p < 0.05). The rest of the immunological parameters analyzed remained unchanged. CONCLUSION: Moderate beer consumption produced an immunomodulatory effect in a healthy adult Spanish population; this effect appears to be more relevant in women than in men. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/17726314/Changes_in_the_immune_system_after_moderate_beer_consumption_ L2 - https://www.karger.com?DOI=10.1159/000107679 DB - PRIME DP - Unbound Medicine ER -