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Incidence and subtypes of dementia in three elderly populations of central Spain.
J Neurol Sci. 2008 Jan 15; 264(1-2):63-72.JN

Abstract

OBJECTIVE

To assess age-, gender, and subtype-specific incidence rates of dementia in three populations in central Spain using data from the Neurological Disorders in Central Spain (NEDICES), a population-based survey of elderly participants.

METHODS

Individuals were evaluated at baseline (1994-1995) and at follow-up (a median of 3.2 years later in 1997-1998). The evaluation included a screening questionnaire for dementia and a neurological assessment, when possible.

RESULTS

Of 5278 participants evaluated at baseline, there were 306 prevalent dementia cases. One hundred and sixty-one incident dementia cases were identified among 3,891 individuals assessed at follow-up. The large majority had Alzheimer's disease (AD): 115 (71.4%) AD, 18 (11.2%) vascular dementia (VaD), 11 (6.8%) dementia associated with parkinsonism, 11 (6.8%) undetermined etiology, and 6 (3.7%) secondary dementia. Average annual incidence rates (per 1,000 person-years) in the population aged 65 to 90 and over years, adjusted to the standard European population, were 10.6 (95% CI, 8.9 to 12.3) for dementia, 7.4 (95% CI=6.0 to 8.8) for AD, and 1.4 (95% CI=0.6 to 2.3) for VaD. Age-specific incidence rates of dementia and AD increased exponentially with advancing age. Age, stroke and illiteracy were independent risk factors for dementia and AD. Aggregation of vascular risk factors was related to a higher risk of both VaD and AD.

CONCLUSIONS

In the NEDICES study, incidence of dementia increased with age beyond age 85 and AD was the most frequent type of dementia. The risk of AD and VaD increased with the number of vascular risk factors.

Authors+Show Affiliations

Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17727890

Citation

Bermejo-Pareja, F, et al. "Incidence and Subtypes of Dementia in Three Elderly Populations of Central Spain." Journal of the Neurological Sciences, vol. 264, no. 1-2, 2008, pp. 63-72.
Bermejo-Pareja F, Benito-León J, Vega S, et al. Incidence and subtypes of dementia in three elderly populations of central Spain. J Neurol Sci. 2008;264(1-2):63-72.
Bermejo-Pareja, F., Benito-León, J., Vega, S., Medrano, M. J., & Román, G. C. (2008). Incidence and subtypes of dementia in three elderly populations of central Spain. Journal of the Neurological Sciences, 264(1-2), 63-72.
Bermejo-Pareja F, et al. Incidence and Subtypes of Dementia in Three Elderly Populations of Central Spain. J Neurol Sci. 2008 Jan 15;264(1-2):63-72. PubMed PMID: 17727890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and subtypes of dementia in three elderly populations of central Spain. AU - Bermejo-Pareja,F, AU - Benito-León,J, AU - Vega,S, AU - Medrano,M J, AU - Román,G C, AU - ,, Y1 - 2007/08/28/ PY - 2007/03/11/received PY - 2007/06/15/revised PY - 2007/07/20/accepted PY - 2007/8/31/pubmed PY - 2008/4/9/medline PY - 2007/8/31/entrez SP - 63 EP - 72 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 264 IS - 1-2 N2 - OBJECTIVE: To assess age-, gender, and subtype-specific incidence rates of dementia in three populations in central Spain using data from the Neurological Disorders in Central Spain (NEDICES), a population-based survey of elderly participants. METHODS: Individuals were evaluated at baseline (1994-1995) and at follow-up (a median of 3.2 years later in 1997-1998). The evaluation included a screening questionnaire for dementia and a neurological assessment, when possible. RESULTS: Of 5278 participants evaluated at baseline, there were 306 prevalent dementia cases. One hundred and sixty-one incident dementia cases were identified among 3,891 individuals assessed at follow-up. The large majority had Alzheimer's disease (AD): 115 (71.4%) AD, 18 (11.2%) vascular dementia (VaD), 11 (6.8%) dementia associated with parkinsonism, 11 (6.8%) undetermined etiology, and 6 (3.7%) secondary dementia. Average annual incidence rates (per 1,000 person-years) in the population aged 65 to 90 and over years, adjusted to the standard European population, were 10.6 (95% CI, 8.9 to 12.3) for dementia, 7.4 (95% CI=6.0 to 8.8) for AD, and 1.4 (95% CI=0.6 to 2.3) for VaD. Age-specific incidence rates of dementia and AD increased exponentially with advancing age. Age, stroke and illiteracy were independent risk factors for dementia and AD. Aggregation of vascular risk factors was related to a higher risk of both VaD and AD. CONCLUSIONS: In the NEDICES study, incidence of dementia increased with age beyond age 85 and AD was the most frequent type of dementia. The risk of AD and VaD increased with the number of vascular risk factors. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17727890/Incidence_and_subtypes_of_dementia_in_three_elderly_populations_of_central_Spain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00491-1 DB - PRIME DP - Unbound Medicine ER -