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Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test.
Eur Neuropsychopharmacol. 2008 May; 18(5):323-32.EN

Abstract

In the present study we evaluated the involvement of l-arginine/nitric oxide (NO)/cGMP pathway in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test (FST). Lithium, at 30 and 100 mg/kg, significantly reduced the immobility times of mice in the FST, whereas at lower doses (0.5, 5 and 10 mg/kg) had no effect on the immobility time. The NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), at 10 and 30 mg/kg, and the selective neuronal NOS inhibitor N(omega)-propyl-L-arginine (L-NPA), at 5 and 15 mg/kg, had no significant effects on the FST, whereas they significantly decreased the immobility time at 100 and 30 mg/kg, respectively. Combination of non-effective dose of lithium (10 mg/kg) with low doses of L-NAME (30 mg/kg) or L-NPA (15 mg/kg) significantly reduced the immobility times in the FST. Moreover, the guanylyl cyclase inhibitor ODQ at 50 mg/kg significantly decreased the immobility time of mice, whereas it had not significant effects on the FST at 2, 10 and 20 mg/kg. Combination of lithium (10 mg/kg) with 20 mg/kg ODQ significantly decreased the immobility times in the FST. Non-effective doses of L-arginine (750 mg/kg) or sildenafil (5 mg/kg) significantly reversed the antidepressant-like effect of 30 mg/kg lithium in the FST. Neither of the drugs had effect on the locomotor activity. These data indicate the involvement of L-arginine/NO/cGMP pathway in the antidepressant-like effect of lithium in the mouse FST and also might suggest the concurrent administration of NOS inhibitors and lithium as an appropriate strategy for treatment of depression.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Medical Sciences/University of Tehran, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17728109

Citation

Ghasemi, Mehdi, et al. "Nitric Oxide Involvement in the Antidepressant-like Effects of Acute Lithium Administration in the Mouse Forced Swimming Test." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 18, no. 5, 2008, pp. 323-32.
Ghasemi M, Sadeghipour H, Mosleh A, et al. Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharmacol. 2008;18(5):323-32.
Ghasemi, M., Sadeghipour, H., Mosleh, A., Sadeghipour, H. R., Mani, A. R., & Dehpour, A. R. (2008). Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 18(5), 323-32.
Ghasemi M, et al. Nitric Oxide Involvement in the Antidepressant-like Effects of Acute Lithium Administration in the Mouse Forced Swimming Test. Eur Neuropsychopharmacol. 2008;18(5):323-32. PubMed PMID: 17728109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. AU - Ghasemi,Mehdi, AU - Sadeghipour,Hamed, AU - Mosleh,Afsaneh, AU - Sadeghipour,Hamid Reza, AU - Mani,Ali Reza, AU - Dehpour,Ahmad Reza, Y1 - 2007/08/28/ PY - 2007/02/17/received PY - 2007/07/26/revised PY - 2007/07/31/accepted PY - 2007/8/31/pubmed PY - 2008/7/3/medline PY - 2007/8/31/entrez SP - 323 EP - 32 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 18 IS - 5 N2 - In the present study we evaluated the involvement of l-arginine/nitric oxide (NO)/cGMP pathway in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test (FST). Lithium, at 30 and 100 mg/kg, significantly reduced the immobility times of mice in the FST, whereas at lower doses (0.5, 5 and 10 mg/kg) had no effect on the immobility time. The NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), at 10 and 30 mg/kg, and the selective neuronal NOS inhibitor N(omega)-propyl-L-arginine (L-NPA), at 5 and 15 mg/kg, had no significant effects on the FST, whereas they significantly decreased the immobility time at 100 and 30 mg/kg, respectively. Combination of non-effective dose of lithium (10 mg/kg) with low doses of L-NAME (30 mg/kg) or L-NPA (15 mg/kg) significantly reduced the immobility times in the FST. Moreover, the guanylyl cyclase inhibitor ODQ at 50 mg/kg significantly decreased the immobility time of mice, whereas it had not significant effects on the FST at 2, 10 and 20 mg/kg. Combination of lithium (10 mg/kg) with 20 mg/kg ODQ significantly decreased the immobility times in the FST. Non-effective doses of L-arginine (750 mg/kg) or sildenafil (5 mg/kg) significantly reversed the antidepressant-like effect of 30 mg/kg lithium in the FST. Neither of the drugs had effect on the locomotor activity. These data indicate the involvement of L-arginine/NO/cGMP pathway in the antidepressant-like effect of lithium in the mouse FST and also might suggest the concurrent administration of NOS inhibitors and lithium as an appropriate strategy for treatment of depression. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/17728109/Nitric_oxide_involvement_in_the_antidepressant_like_effects_of_acute_lithium_administration_in_the_mouse_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(07)00154-X DB - PRIME DP - Unbound Medicine ER -