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5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus.
Eur Neuropsychopharmacol. 2008 Apr; 18(4):286-94.EN

Abstract

We evaluated the involvement of dorsal hippocampus (DH) 5-HT1A receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-HT neurons in the median raphe nucleus (MRN). To this end, we used the rat elevated T-maze test of anxiety. The results showed that intra-DH injection of the 5-HT1A/7 agonist 8-OH-DPAT facilitated inhibitory avoidance, an anxiogenic effect, without affecting escape. Microinjection of the 5-HT1A antagonist WAY-100635 was ineffective. In the elevated T-maze, inhibitory avoidance and escape have been related to generalized anxiety and panic disorders, respectively. Intra-MRN administration of the excitatory amino acid kainic acid, which non-selectively stimulates 5-HT neurons in this brain area facilitated inhibitory avoidance and impaired escape performance, but also affected locomotion. Intra-MRN injection of WAY-100635, which has a disinhibitory effect on the activity of 5-HT neurons in this midbrain area, only facilitated inhibitory avoidance. Pre-administration of WAY-100635 into the DH blocked the behavioral effect of intra-MRN injection of WAY-100635, but not of kainic acid. These results indicate that DH 5-HT1A receptors mediate the anxiogenic effect induced by the selective stimulation of 5-HT neurons in the MRN.

Authors+Show Affiliations

Dos Santos L
Department of Psychology and Education, FFCLRP, University of São Paulo, 14040-901, Ribeirão Preto-SP, Brazil.
de Andrade TG
No affiliation info available
Zangrossi Junior H
No affiliation info available

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsAnxietyBehavior, AnimalElectric StimulationExcitatory Amino Acid AgonistsHippocampusKainic AcidMaleMicroinjectionsMotor ActivityNeuronsPiperazinesPyridinesRaphe NucleiRatsRats, WistarReceptor, Serotonin, 5-HT1ASerotoninSerotonin AntagonistsSerotonin Receptor Agonists

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17728111

Citation

Dos Santos, Lucinéia, et al. "5-HT1A Receptors in the Dorsal Hippocampus Mediate the Anxiogenic Effect Induced By the Stimulation of 5-HT Neurons in the Median Raphe Nucleus." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 18, no. 4, 2008, pp. 286-94.
Dos Santos L, de Andrade TG, Zangrossi Junior H. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. Eur Neuropsychopharmacol. 2008;18(4):286-94.
Dos Santos, L., de Andrade, T. G., & Zangrossi Junior, H. (2008). 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 18(4), 286-94.
Dos Santos L, de Andrade TG, Zangrossi Junior H. 5-HT1A Receptors in the Dorsal Hippocampus Mediate the Anxiogenic Effect Induced By the Stimulation of 5-HT Neurons in the Median Raphe Nucleus. Eur Neuropsychopharmacol. 2008;18(4):286-94. PubMed PMID: 17728111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. AU - Dos Santos,Lucinéia, AU - de Andrade,Telma G C S, AU - Zangrossi Junior,Hélio, Y1 - 2007/08/28/ PY - 2007/01/29/received PY - 2007/05/22/revised PY - 2007/07/18/accepted PY - 2007/8/31/pubmed PY - 2008/4/24/medline PY - 2007/8/31/entrez SP - 286 EP - 94 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 18 IS - 4 N2 - We evaluated the involvement of dorsal hippocampus (DH) 5-HT1A receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-HT neurons in the median raphe nucleus (MRN). To this end, we used the rat elevated T-maze test of anxiety. The results showed that intra-DH injection of the 5-HT1A/7 agonist 8-OH-DPAT facilitated inhibitory avoidance, an anxiogenic effect, without affecting escape. Microinjection of the 5-HT1A antagonist WAY-100635 was ineffective. In the elevated T-maze, inhibitory avoidance and escape have been related to generalized anxiety and panic disorders, respectively. Intra-MRN administration of the excitatory amino acid kainic acid, which non-selectively stimulates 5-HT neurons in this brain area facilitated inhibitory avoidance and impaired escape performance, but also affected locomotion. Intra-MRN injection of WAY-100635, which has a disinhibitory effect on the activity of 5-HT neurons in this midbrain area, only facilitated inhibitory avoidance. Pre-administration of WAY-100635 into the DH blocked the behavioral effect of intra-MRN injection of WAY-100635, but not of kainic acid. These results indicate that DH 5-HT1A receptors mediate the anxiogenic effect induced by the selective stimulation of 5-HT neurons in the MRN. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/17728111/5_HT1A_receptors_in_the_dorsal_hippocampus_mediate_the_anxiogenic_effect_induced_by_the_stimulation_of_5_HT_neurons_in_the_median_raphe_nucleus_ DB - PRIME DP - Unbound Medicine ER -