TY - JOUR T1 - Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines. AU - Zheng,Bao-Lei, AU - Liu,Quan-Zhong, AU - Guo,Chuan-Sheng, AU - Wang,Xue-Lian, AU - He,Long, Y1 - 2007/08/14/ PY - 2007/8/31/pubmed PY - 2007/8/31/medline PY - 2007/8/31/entrez SP - 2913 EP - 5 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 5 IS - 18 N2 - Highly enantioselective aldol reactions of aldehydes with cyclic ketones catalyzed by a primary amine derived from cinchonine are reported. Aromatic aldehydes reacted with various cyclic ketones cleanly to afford the anti-aldol adducts in up to 99% yield, with good diastereoselectivities (up to 9 : 1) and excellent enantioselectivities (up to 99% ee). SN - 1477-0520 UR - https://www.unboundmedicine.com/medline/citation/17728855/Highly_enantioselective_direct_aldol_reaction_catalyzed_by_cinchona_derived_primary_amines_ L2 - https://doi.org/10.1039/b711164a DB - PRIME DP - Unbound Medicine ER -