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The diagnosis and treatment of donovanosis (granuloma inguinale).
Genitourin Med. 1991 Dec; 67(6):441-52.GM

Abstract

Donovanosis is a predominantly tropical cause of genital ulcer occurring chiefly in small endemic foci in all continents except Europe. Diagnosis requires the careful collection, staining and examination of smears or biopsies of characteristic genital and, occasionally, extragenital lesions for demonstration of the pathognomonic Donovan bodies (Calymmatobacterium granulomatis) within histiocytes. Successful isolation of C. granulomatis has rarely proved feasible, the last report being in 1962. Donovanosis has a characteristic histopathological picture which occasionally simulates epithelioma. The antibiotics reported as showing good activity in donovanosis are those with good activity against gram negative bacilli and whose lipid solubility ensures good intracellular penetration. They include streptomycin, chloramphenicol, erythromycin, lincomycin, cotrimoxazole and the tetracyclines. More recently, good results have been reported with norfloxacin and thiamphenicol. The treatment of donovanosis in pregnant women and patients with AIDS poses special problems. Complications of donovanosis such as elephantiasis, stricture and pelvic abscess may require surgery. Contacts should be traced for examination but only treated if lesions are found.

Authors+Show Affiliations

London School of Hygiene and Tropical Medicine, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1774048

Citation

Richens, J. "The Diagnosis and Treatment of Donovanosis (granuloma Inguinale)." Genitourinary Medicine, vol. 67, no. 6, 1991, pp. 441-52.
Richens J. The diagnosis and treatment of donovanosis (granuloma inguinale). Genitourin Med. 1991;67(6):441-52.
Richens, J. (1991). The diagnosis and treatment of donovanosis (granuloma inguinale). Genitourinary Medicine, 67(6), 441-52.
Richens J. The Diagnosis and Treatment of Donovanosis (granuloma Inguinale). Genitourin Med. 1991;67(6):441-52. PubMed PMID: 1774048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnosis and treatment of donovanosis (granuloma inguinale). A1 - Richens,J, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 441 EP - 52 JF - Genitourinary medicine JO - Genitourin Med VL - 67 IS - 6 N2 - Donovanosis is a predominantly tropical cause of genital ulcer occurring chiefly in small endemic foci in all continents except Europe. Diagnosis requires the careful collection, staining and examination of smears or biopsies of characteristic genital and, occasionally, extragenital lesions for demonstration of the pathognomonic Donovan bodies (Calymmatobacterium granulomatis) within histiocytes. Successful isolation of C. granulomatis has rarely proved feasible, the last report being in 1962. Donovanosis has a characteristic histopathological picture which occasionally simulates epithelioma. The antibiotics reported as showing good activity in donovanosis are those with good activity against gram negative bacilli and whose lipid solubility ensures good intracellular penetration. They include streptomycin, chloramphenicol, erythromycin, lincomycin, cotrimoxazole and the tetracyclines. More recently, good results have been reported with norfloxacin and thiamphenicol. The treatment of donovanosis in pregnant women and patients with AIDS poses special problems. Complications of donovanosis such as elephantiasis, stricture and pelvic abscess may require surgery. Contacts should be traced for examination but only treated if lesions are found. SN - 0266-4348 UR - https://www.unboundmedicine.com/medline/citation/1774048/The_diagnosis_and_treatment_of_donovanosis__granuloma_inguinale__ L2 - https://sti.bmj.com/lookup/pmidlookup?view=long&pmid=1774048 DB - PRIME DP - Unbound Medicine ER -