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Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies.
Am J Epidemiol. 2007 Nov 15; 166(10):1159-73.AJ

Abstract

Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928 controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer (central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59). These results indicate that periodontal disease (as indicated by poor condition of the mouth and missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and esophagus.

Authors+Show Affiliations

International Agency for Research on Cancer, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17761691

Citation

Guha, Neela, et al. "Oral Health and Risk of Squamous Cell Carcinoma of the Head and Neck and Esophagus: Results of Two Multicentric Case-control Studies." American Journal of Epidemiology, vol. 166, no. 10, 2007, pp. 1159-73.
Guha N, Boffetta P, Wünsch Filho V, et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol. 2007;166(10):1159-73.
Guha, N., Boffetta, P., Wünsch Filho, V., Eluf Neto, J., Shangina, O., Zaridze, D., Curado, M. P., Koifman, S., Matos, E., Menezes, A., Szeszenia-Dabrowska, N., Fernandez, L., Mates, D., Daudt, A. W., Lissowska, J., Dikshit, R., & Brennan, P. (2007). Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. American Journal of Epidemiology, 166(10), 1159-73.
Guha N, et al. Oral Health and Risk of Squamous Cell Carcinoma of the Head and Neck and Esophagus: Results of Two Multicentric Case-control Studies. Am J Epidemiol. 2007 Nov 15;166(10):1159-73. PubMed PMID: 17761691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. AU - Guha,Neela, AU - Boffetta,Paolo, AU - Wünsch Filho,Victor, AU - Eluf Neto,Jose, AU - Shangina,Oxana, AU - Zaridze,David, AU - Curado,Maria Paula, AU - Koifman,Sergio, AU - Matos,Elena, AU - Menezes,Ana, AU - Szeszenia-Dabrowska,Neonila, AU - Fernandez,Leticia, AU - Mates,Dana, AU - Daudt,Alexander W, AU - Lissowska,Jolanta, AU - Dikshit,Rajesh, AU - Brennan,Paul, Y1 - 2007/08/30/ PY - 2007/9/1/pubmed PY - 2007/12/6/medline PY - 2007/9/1/entrez SP - 1159 EP - 73 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 10 N2 - Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928 controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer (central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59). These results indicate that periodontal disease (as indicated by poor condition of the mouth and missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and esophagus. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/17761691/Oral_health_and_risk_of_squamous_cell_carcinoma_of_the_head_and_neck_and_esophagus:_results_of_two_multicentric_case_control_studies_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm193 DB - PRIME DP - Unbound Medicine ER -