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Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock.
Curr Opin Crit Care. 2007 Oct; 13(5):586-91.CO

Abstract

PURPOSE OF REVIEW

Treatment protocols targeting the rapid administration of appropriate antibiotics and hemodynamic support are now recognized as a key measure in the initial care of patients presenting with severe sepsis and septic shock. Strong evidence exists showing that time parameters, particularly in the emergency department, are as important as the nature of the treatment administered. The concept of sepsis bundles integrates evidence-based and time-sensitive issues, derived from international sepsis guidelines, to ensure that all eligible patients receive the right treatment as early as possible.

RECENT FINDINGS

Several studies have demonstrated that patients resuscitated according to sepsis bundles had a significantly lower mortality.

SUMMARY

It seems logical that timely and protocolized treatment for patients presenting with severe sepsis and septic shock will impact on outcome. It remains to be shown, however, whether translating evidence into clinical practice will increase adherence to the bundles and positively impact on survival.

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Authors+Show Affiliations

Nobre V
aIntensive Care, Switzerland bEmergency Department, University Hospitals of Geneva, Geneva, Switzerland.
Sarasin FP
No affiliation info available
Pugin J
No affiliation info available

MeSH

Anti-Bacterial AgentsCardiotonic AgentsClinical ProtocolsCritical CareDopamineDrug Administration ScheduleErythrocyte TransfusionFluid TherapyHemodynamicsHumansMonitoring, PhysiologicResuscitationSepsisShock, SepticTime Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17762240

Citation

Nobre, Vandack, et al. "Prompt Antibiotic Administration and Goal-directed Hemodynamic Support in Patients With Severe Sepsis and Septic Shock." Current Opinion in Critical Care, vol. 13, no. 5, 2007, pp. 586-91.
Nobre V, Sarasin FP, Pugin J. Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock. Curr Opin Crit Care. 2007;13(5):586-91.
Nobre, V., Sarasin, F. P., & Pugin, J. (2007). Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock. Current Opinion in Critical Care, 13(5), 586-91.
Nobre V, Sarasin FP, Pugin J. Prompt Antibiotic Administration and Goal-directed Hemodynamic Support in Patients With Severe Sepsis and Septic Shock. Curr Opin Crit Care. 2007;13(5):586-91. PubMed PMID: 17762240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock. AU - Nobre,Vandack, AU - Sarasin,François P, AU - Pugin,Jérôme, PY - 2007/9/1/pubmed PY - 2008/3/5/medline PY - 2007/9/1/entrez SP - 586 EP - 91 JF - Current opinion in critical care JO - Curr Opin Crit Care VL - 13 IS - 5 N2 - PURPOSE OF REVIEW: Treatment protocols targeting the rapid administration of appropriate antibiotics and hemodynamic support are now recognized as a key measure in the initial care of patients presenting with severe sepsis and septic shock. Strong evidence exists showing that time parameters, particularly in the emergency department, are as important as the nature of the treatment administered. The concept of sepsis bundles integrates evidence-based and time-sensitive issues, derived from international sepsis guidelines, to ensure that all eligible patients receive the right treatment as early as possible. RECENT FINDINGS: Several studies have demonstrated that patients resuscitated according to sepsis bundles had a significantly lower mortality. SUMMARY: It seems logical that timely and protocolized treatment for patients presenting with severe sepsis and septic shock will impact on outcome. It remains to be shown, however, whether translating evidence into clinical practice will increase adherence to the bundles and positively impact on survival. SN - 1070-5295 UR - https://www.unboundmedicine.com/medline/citation/17762240/Prompt_antibiotic_administration_and_goal_directed_hemodynamic_support_in_patients_with_severe_sepsis_and_septic_shock_ L2 - https://doi.org/10.1097/MCC.0b013e3282e7d8e1 DB - PRIME DP - Unbound Medicine ER -