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Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats.
Behav Pharmacol. 2007 Sep; 18(5-6):563-9.BP

Abstract

Like other recreational drugs, cannabinoids may produce different effects in men and women. In this study we measured the effects of delta9-tetrahydrocannabinol (THC) on spatial learning in two groups that are underrepresented in drug research--females and adolescents. In the first experiment, adolescent (postnatal day 30) and adult (postnatal day 70) rats of both sexes were treated subchronically with 5.0 mg/kg THC or vehicle for five consecutive days. Thirty minutes after each daily injection, they were tested on the spatial version of the Morris water maze task. In the second experiment, a separate group of adolescent and adult rats of both sexes was treated with 5.0 mg/kg THC or vehicle daily for 21 days and tested, 4 weeks later, on the spatial version of the water maze. Subchronic THC impaired spatial learning, and this effect was dependent upon both the age and sex of the animals tested. Prior exposure to chronic THC, however, did not cause any long-lasting spatial learning deficits. On the basis of our previous studies in male rats the third experiment assessed the dose-response relationship for the effects of THC on spatial learning and memory in female animals. We found that subchronic THC treatment (2.5, 5.0, or 10.0 mg/kg, intraperitoneally) disrupted learning in both adolescents and adults, but with greater effects at higher doses in adolescents compared with adults. The developmental sensitivity to subchronic THC confirms previous work carried out in our laboratory, and the sex-dependent effects highlight the importance of including females in drug abuse and addiction research.

Authors+Show Affiliations

Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17762524

Citation

Cha, Young May, et al. "Sex Differences in the Effects of Delta9-tetrahydrocannabinol On Spatial Learning in Adolescent and Adult Rats." Behavioural Pharmacology, vol. 18, no. 5-6, 2007, pp. 563-9.
Cha YM, Jones KH, Kuhn CM, et al. Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behav Pharmacol. 2007;18(5-6):563-9.
Cha, Y. M., Jones, K. H., Kuhn, C. M., Wilson, W. A., & Swartzwelder, H. S. (2007). Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behavioural Pharmacology, 18(5-6), 563-9.
Cha YM, et al. Sex Differences in the Effects of Delta9-tetrahydrocannabinol On Spatial Learning in Adolescent and Adult Rats. Behav Pharmacol. 2007;18(5-6):563-9. PubMed PMID: 17762524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats. AU - Cha,Young May, AU - Jones,Katherine H, AU - Kuhn,Cynthia M, AU - Wilson,Wilkie A, AU - Swartzwelder,Harry Scott, PY - 2007/9/1/pubmed PY - 2007/10/24/medline PY - 2007/9/1/entrez SP - 563 EP - 9 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 18 IS - 5-6 N2 - Like other recreational drugs, cannabinoids may produce different effects in men and women. In this study we measured the effects of delta9-tetrahydrocannabinol (THC) on spatial learning in two groups that are underrepresented in drug research--females and adolescents. In the first experiment, adolescent (postnatal day 30) and adult (postnatal day 70) rats of both sexes were treated subchronically with 5.0 mg/kg THC or vehicle for five consecutive days. Thirty minutes after each daily injection, they were tested on the spatial version of the Morris water maze task. In the second experiment, a separate group of adolescent and adult rats of both sexes was treated with 5.0 mg/kg THC or vehicle daily for 21 days and tested, 4 weeks later, on the spatial version of the water maze. Subchronic THC impaired spatial learning, and this effect was dependent upon both the age and sex of the animals tested. Prior exposure to chronic THC, however, did not cause any long-lasting spatial learning deficits. On the basis of our previous studies in male rats the third experiment assessed the dose-response relationship for the effects of THC on spatial learning and memory in female animals. We found that subchronic THC treatment (2.5, 5.0, or 10.0 mg/kg, intraperitoneally) disrupted learning in both adolescents and adults, but with greater effects at higher doses in adolescents compared with adults. The developmental sensitivity to subchronic THC confirms previous work carried out in our laboratory, and the sex-dependent effects highlight the importance of including females in drug abuse and addiction research. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/17762524/Sex_differences_in_the_effects_of_delta9_tetrahydrocannabinol_on_spatial_learning_in_adolescent_and_adult_rats_ L2 - https://doi.org/10.1097/FBP.0b013e3282ee7b7e DB - PRIME DP - Unbound Medicine ER -