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Use of compaction energetics for understanding particle deformation mechanism.
Pharm Dev Technol. 2007; 12(4):405-14.PD

Abstract

A primary goal of the current work was to examine the potential use of compaction energetics as a tool to predict particle deformation mechanism. Three deformation models, namely, those developed by Heckel, Walker, and Gurnham, were first used to evaluate the deformation mechanisms of 11 commonly used excipients. To complement the information gained from the deformation models, the mechanical energy used in tablet formation was then examined. It has been found that the sum of the work in the compression and decompression phases (plastic work) is a relatively good indicator of a material's plasticity. Conclusions based on this indicator regarding deformation mechanism for the different diluents used were in good agreement with those obtained from the different deformation models studied.

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Authors+Show Affiliations

Aburub A
Pharmaceutical Sciences R&D, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA. aburub_aktham@lilly.com
Mishra D
No affiliation info available
Buckner I
No affiliation info available

MeSH

Chemistry, PharmaceuticalCompressive StrengthElasticityExcipientsModels, TheoreticalPharmaceutical PreparationsPorosityPressureRheologyTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17763145

Citation

Aburub, Aktham, et al. "Use of Compaction Energetics for Understanding Particle Deformation Mechanism." Pharmaceutical Development and Technology, vol. 12, no. 4, 2007, pp. 405-14.
Aburub A, Mishra D, Buckner I. Use of compaction energetics for understanding particle deformation mechanism. Pharm Dev Technol. 2007;12(4):405-14.
Aburub, A., Mishra, D., & Buckner, I. (2007). Use of compaction energetics for understanding particle deformation mechanism. Pharmaceutical Development and Technology, 12(4), 405-14.
Aburub A, Mishra D, Buckner I. Use of Compaction Energetics for Understanding Particle Deformation Mechanism. Pharm Dev Technol. 2007;12(4):405-14. PubMed PMID: 17763145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of compaction energetics for understanding particle deformation mechanism. AU - Aburub,Aktham, AU - Mishra,Dinesh, AU - Buckner,Ira, PY - 2007/9/1/pubmed PY - 2007/11/6/medline PY - 2007/9/1/entrez SP - 405 EP - 14 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 12 IS - 4 N2 - A primary goal of the current work was to examine the potential use of compaction energetics as a tool to predict particle deformation mechanism. Three deformation models, namely, those developed by Heckel, Walker, and Gurnham, were first used to evaluate the deformation mechanisms of 11 commonly used excipients. To complement the information gained from the deformation models, the mechanical energy used in tablet formation was then examined. It has been found that the sum of the work in the compression and decompression phases (plastic work) is a relatively good indicator of a material's plasticity. Conclusions based on this indicator regarding deformation mechanism for the different diluents used were in good agreement with those obtained from the different deformation models studied. SN - 1083-7450 UR - https://www.unboundmedicine.com/medline/citation/17763145/Use_of_compaction_energetics_for_understanding_particle_deformation_mechanism_ L2 - https://www.tandfonline.com/doi/full/10.1080/10837450701366952 DB - PRIME DP - Unbound Medicine ER -