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Radionuclide staging of renal function in type 1 diabetes mellitus.
Ren Fail. 2007; 29(6):685-91.RF

Abstract

AIM

The aim of this study was to assess renal function in different stages of type 1 diabetes mellitus by radionuclide methods. Additionally, glomerular and tubular functions were correlated with urinary albumin (UAER) and N-acetyl-beta-D-glucosaminidase (NAGA) excretion rates.

PATIENTS AND METHODS

Fifty-three patients with diabetes mellitus were classified into four groups: normoalbuminuric (NA, 18 patients), microalbuminuric (MiA, 12 patients), macroalbuminuric (MaA, 13 patients), and chronic renal failure group (CRF, 10 patients). Glomerular filtration rate (GFR) was estimated by diethylenetriamine pentaacetic acid-technetium 99m ((99m)Tc-DTPA) clearance rate while tubular function was calculated as a percentage of net injected activity fixed in both kidneys, 4 h after intravenous injection of dimercaptosuccinate acid-technetium 99m ((99m)Tc-DMSA). Additionally, (99m)Tc-DTPA clearance was correlated with estimated GFR (eGFR) by using modified Modification of Diet in Renal Disease (MDRD) Study Group formula.

RESULTS

(99m)Tc-DTPA clearance and (99m)Tc-DMSA fixation were found significantly higher in normoalbuminuric group (p < 0.05 and p < 0.02, respectively), unchanged in microalbuminuric group (p > 0.05, p > 0.05), and decreased in both macroalbuminuric (p < 0.0001, p < 0.00001) and chronic renal failure group (p < 0.0001, p < 0.00001). Renal function was denoted as normal, increased (hyperfunction), or decreased (hypofunction). It was found normal in a high percentage of patients with normalbuminuria (filtration 44.4%, fixation 72.2% pts) and microalbuminuria (66.7% and 66.7%). Renal hyperfunction was not only found frequent in normalbuminuric group (55.6% and 27.8%), but was also recorded in microalbuminuric group (8.3% and 8.3%). Renal hypofunction was present in all macroalbuminuric patients and in one-quarter of those with microalbuminuria as well. Such distribution of renal function conditions indicated normalbuminuric and microalbuminiric groups functionally heterogeneous. Regression analysis showed a significant correlation between (99m)Tc-DTPA clearance and eGFR in MaA and CRF groups only. Although urinary NAGA excretion rate was shown as a less sensitive staging parameter, being significantly increased when compared to control group only in MaA and CRF groups (p < 0.05), it significantly correlated with (99m)Tc-DTPA clearance rate (r = -0.485, p = 0.0004) and (99m)Tc-DMSA tubular fixation (r = -0.526, p = 0.0002).

CONCLUSIONS

The results of this study favor the performance of radionuclide studies together with the determination of urinary albumin excretion rate in patients with type 1 diabetes mellitus in order to achieve more reliable staging of diabetic kidney disease. The demonstration of glomerular hyperfiltration and tubular hyperfunction by radiopharmaceuticals contributes to the early detection of diabetic kidney disease, while the quantification of renal function enables the follow-up of the progressive function loss in the later course of the disease.

Authors+Show Affiliations

Department of Nuclear Medicine, Clinical Center and Faculty of Medicine, University of Nis, Serbia. mrajic@EUnet.yuNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17763163

Citation

Rajic, Milena, et al. "Radionuclide Staging of Renal Function in Type 1 Diabetes Mellitus." Renal Failure, vol. 29, no. 6, 2007, pp. 685-91.
Rajic M, Ilic S, Vlajkovic M, et al. Radionuclide staging of renal function in type 1 diabetes mellitus. Ren Fail. 2007;29(6):685-91.
Rajic, M., Ilic, S., Vlajkovic, M., Antic, S., Velickovic, L., & Stefanovic, V. (2007). Radionuclide staging of renal function in type 1 diabetes mellitus. Renal Failure, 29(6), 685-91.
Rajic M, et al. Radionuclide Staging of Renal Function in Type 1 Diabetes Mellitus. Ren Fail. 2007;29(6):685-91. PubMed PMID: 17763163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radionuclide staging of renal function in type 1 diabetes mellitus. AU - Rajic,Milena, AU - Ilic,Slobodan, AU - Vlajkovic,Marina, AU - Antic,Slobodan, AU - Velickovic,Ljubinka, AU - Stefanovic,Vladisav, PY - 2007/9/1/pubmed PY - 2007/11/6/medline PY - 2007/9/1/entrez SP - 685 EP - 91 JF - Renal failure JO - Ren Fail VL - 29 IS - 6 N2 - AIM: The aim of this study was to assess renal function in different stages of type 1 diabetes mellitus by radionuclide methods. Additionally, glomerular and tubular functions were correlated with urinary albumin (UAER) and N-acetyl-beta-D-glucosaminidase (NAGA) excretion rates. PATIENTS AND METHODS: Fifty-three patients with diabetes mellitus were classified into four groups: normoalbuminuric (NA, 18 patients), microalbuminuric (MiA, 12 patients), macroalbuminuric (MaA, 13 patients), and chronic renal failure group (CRF, 10 patients). Glomerular filtration rate (GFR) was estimated by diethylenetriamine pentaacetic acid-technetium 99m ((99m)Tc-DTPA) clearance rate while tubular function was calculated as a percentage of net injected activity fixed in both kidneys, 4 h after intravenous injection of dimercaptosuccinate acid-technetium 99m ((99m)Tc-DMSA). Additionally, (99m)Tc-DTPA clearance was correlated with estimated GFR (eGFR) by using modified Modification of Diet in Renal Disease (MDRD) Study Group formula. RESULTS: (99m)Tc-DTPA clearance and (99m)Tc-DMSA fixation were found significantly higher in normoalbuminuric group (p < 0.05 and p < 0.02, respectively), unchanged in microalbuminuric group (p > 0.05, p > 0.05), and decreased in both macroalbuminuric (p < 0.0001, p < 0.00001) and chronic renal failure group (p < 0.0001, p < 0.00001). Renal function was denoted as normal, increased (hyperfunction), or decreased (hypofunction). It was found normal in a high percentage of patients with normalbuminuria (filtration 44.4%, fixation 72.2% pts) and microalbuminuria (66.7% and 66.7%). Renal hyperfunction was not only found frequent in normalbuminuric group (55.6% and 27.8%), but was also recorded in microalbuminuric group (8.3% and 8.3%). Renal hypofunction was present in all macroalbuminuric patients and in one-quarter of those with microalbuminuria as well. Such distribution of renal function conditions indicated normalbuminuric and microalbuminiric groups functionally heterogeneous. Regression analysis showed a significant correlation between (99m)Tc-DTPA clearance and eGFR in MaA and CRF groups only. Although urinary NAGA excretion rate was shown as a less sensitive staging parameter, being significantly increased when compared to control group only in MaA and CRF groups (p < 0.05), it significantly correlated with (99m)Tc-DTPA clearance rate (r = -0.485, p = 0.0004) and (99m)Tc-DMSA tubular fixation (r = -0.526, p = 0.0002). CONCLUSIONS: The results of this study favor the performance of radionuclide studies together with the determination of urinary albumin excretion rate in patients with type 1 diabetes mellitus in order to achieve more reliable staging of diabetic kidney disease. The demonstration of glomerular hyperfiltration and tubular hyperfunction by radiopharmaceuticals contributes to the early detection of diabetic kidney disease, while the quantification of renal function enables the follow-up of the progressive function loss in the later course of the disease. SN - 0886-022X UR - https://www.unboundmedicine.com/medline/citation/17763163/Radionuclide_staging_of_renal_function_in_type_1_diabetes_mellitus_ L2 - https://www.tandfonline.com/doi/full/10.1080/08860220701460061 DB - PRIME DP - Unbound Medicine ER -