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Pathogenesis of endometriosis: the role of defective 'immunosurveillance'.
Eur J Contracept Reprod Health Care. 2007 Sep; 12(3):194-202.EJ

Abstract

OBJECTIVE

To analyse the aetiopathogenesis and the role of defective 'immunosurveillance' in endometriosis.

METHOD

Review of studies on the pathogenesis of endometriosis, focusing particularly on novel molecules which express adhesive or proteolytic properties. Hypotheses addressing the role of oxidative stress in endometriosis were also reviewed.

RESULTS

Endometriosis is a multifactorial disease associated with a general inflammatory response aiming to clear the peritoneal cavity from the ectopic endometriotic cells and tissue. Modern theories suggest that this inflammatory response creates an environment that may promote implantation and proliferation due to defective 'immunosurveillance'.

CONCLUSION

The modern interpretation of the theory of reflux menstruation holds that women destined to develop endometriosis have a deficient immune system, which cannot defend against regurgitated endometrial cells. New findings on genetics, immune modulation, and secreted products of endometriotic lesions of affected women have given insight into the pathogenesis of this disorder and may serve as the background for new treatments of endometriosis-associated pain and infertility.

Authors+Show Affiliations

2nd Department of Obstetrics and Gynaecology, University of Athens, Aretaieion Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17763257

Citation

Christodoulakos, George, et al. "Pathogenesis of Endometriosis: the Role of Defective 'immunosurveillance'." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 12, no. 3, 2007, pp. 194-202.
Christodoulakos G, Augoulea A, Lambrinoudaki I, et al. Pathogenesis of endometriosis: the role of defective 'immunosurveillance'. Eur J Contracept Reprod Health Care. 2007;12(3):194-202.
Christodoulakos, G., Augoulea, A., Lambrinoudaki, I., Sioulas, V., & Creatsas, G. (2007). Pathogenesis of endometriosis: the role of defective 'immunosurveillance'. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 12(3), 194-202.
Christodoulakos G, et al. Pathogenesis of Endometriosis: the Role of Defective 'immunosurveillance'. Eur J Contracept Reprod Health Care. 2007;12(3):194-202. PubMed PMID: 17763257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of endometriosis: the role of defective 'immunosurveillance'. AU - Christodoulakos,George, AU - Augoulea,Areti, AU - Lambrinoudaki,Irene, AU - Sioulas,Vasilios, AU - Creatsas,George, PY - 2007/9/1/pubmed PY - 2008/3/6/medline PY - 2007/9/1/entrez SP - 194 EP - 202 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 12 IS - 3 N2 - OBJECTIVE: To analyse the aetiopathogenesis and the role of defective 'immunosurveillance' in endometriosis. METHOD: Review of studies on the pathogenesis of endometriosis, focusing particularly on novel molecules which express adhesive or proteolytic properties. Hypotheses addressing the role of oxidative stress in endometriosis were also reviewed. RESULTS: Endometriosis is a multifactorial disease associated with a general inflammatory response aiming to clear the peritoneal cavity from the ectopic endometriotic cells and tissue. Modern theories suggest that this inflammatory response creates an environment that may promote implantation and proliferation due to defective 'immunosurveillance'. CONCLUSION: The modern interpretation of the theory of reflux menstruation holds that women destined to develop endometriosis have a deficient immune system, which cannot defend against regurgitated endometrial cells. New findings on genetics, immune modulation, and secreted products of endometriotic lesions of affected women have given insight into the pathogenesis of this disorder and may serve as the background for new treatments of endometriosis-associated pain and infertility. SN - 1362-5187 UR - https://www.unboundmedicine.com/medline/citation/17763257/Pathogenesis_of_endometriosis:_the_role_of_defective_'immunosurveillance'_ L2 - http://www.tandfonline.com/doi/full/10.1080/13625180701387266 DB - PRIME DP - Unbound Medicine ER -