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A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer.
Ann Surg Oncol. 2008 Jan; 15(1):281-5.AS

Abstract

BACKGROUND AND OBJECTIVES

In breast cancer, the expression pattern of CXCR4 may be correlated with the degree of axillary lymph node involvement. The aim of this study was to evaluate the contributing factors that contribute to the correlation between CXCR4 expression and axillary lymph node metastasis in breast cancer.

METHODS

Between August 1997 and August 2002, sections of paraffin-embedded tissue were obtained from 107 patients who received optimal treatment for breast cancer. The expression of CXCR4 was evaluated by immunohistochemical staining.

RESULTS

A significant correlation was found in the expression of nuclear CXCR4 and lymph node metastasis (P = 0.03). We found a significant correlation between a high nuclear expression of CXCR4 and axillary lymphatic metastasis in estrogen and progesterone receptor negative breast cancer (P = 0.01 and P = 0.01). There was a significant correlation between the high expression of nuclear CXCR4 and axillary lymphatic metastasis in comparisons between positive estrogen and/or progesterone receptor expression and negative expression (P = 0.02).

CONCLUSIONS

Our results showed that high expression of nuclear CXCR4 was significantly correlated with lymph node metastasis in breast cancer. The high expression of nuclear CXCR4 in hormone receptor negative breast cancer was associated with a high possibility of lymph node metastasis.

Authors+Show Affiliations

Department of Surgery, Korea University College of Medicine, #126-1 Anam Dong 5 Ga, Sung Buck Gu, Seoul, 136-705, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17763975

Citation

Woo, Sang Uk, et al. "A Significant Correlation Between Nuclear CXCR4 Expression and Axillary Lymph Node Metastasis in Hormonal Receptor Negative Breast Cancer." Annals of Surgical Oncology, vol. 15, no. 1, 2008, pp. 281-5.
Woo SU, Bae JW, Kim CH, et al. A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. Ann Surg Oncol. 2008;15(1):281-5.
Woo, S. U., Bae, J. W., Kim, C. H., Lee, J. B., & Koo, B. W. (2008). A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. Annals of Surgical Oncology, 15(1), 281-5.
Woo SU, et al. A Significant Correlation Between Nuclear CXCR4 Expression and Axillary Lymph Node Metastasis in Hormonal Receptor Negative Breast Cancer. Ann Surg Oncol. 2008;15(1):281-5. PubMed PMID: 17763975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. AU - Woo,Sang Uk, AU - Bae,Jeoung Won, AU - Kim,Chul Hwan, AU - Lee,Jae Bok, AU - Koo,Byum Whan, Y1 - 2007/09/01/ PY - 2007/07/03/received PY - 2007/08/01/accepted PY - 2007/08/01/revised PY - 2007/9/4/pubmed PY - 2008/2/22/medline PY - 2007/9/4/entrez SP - 281 EP - 5 JF - Annals of surgical oncology JO - Ann Surg Oncol VL - 15 IS - 1 N2 - BACKGROUND AND OBJECTIVES: In breast cancer, the expression pattern of CXCR4 may be correlated with the degree of axillary lymph node involvement. The aim of this study was to evaluate the contributing factors that contribute to the correlation between CXCR4 expression and axillary lymph node metastasis in breast cancer. METHODS: Between August 1997 and August 2002, sections of paraffin-embedded tissue were obtained from 107 patients who received optimal treatment for breast cancer. The expression of CXCR4 was evaluated by immunohistochemical staining. RESULTS: A significant correlation was found in the expression of nuclear CXCR4 and lymph node metastasis (P = 0.03). We found a significant correlation between a high nuclear expression of CXCR4 and axillary lymphatic metastasis in estrogen and progesterone receptor negative breast cancer (P = 0.01 and P = 0.01). There was a significant correlation between the high expression of nuclear CXCR4 and axillary lymphatic metastasis in comparisons between positive estrogen and/or progesterone receptor expression and negative expression (P = 0.02). CONCLUSIONS: Our results showed that high expression of nuclear CXCR4 was significantly correlated with lymph node metastasis in breast cancer. The high expression of nuclear CXCR4 in hormone receptor negative breast cancer was associated with a high possibility of lymph node metastasis. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/17763975/A_significant_correlation_between_nuclear_CXCR4_expression_and_axillary_lymph_node_metastasis_in_hormonal_receptor_negative_breast_cancer_ L2 - https://dx.doi.org/10.1245/s10434-007-9595-1 DB - PRIME DP - Unbound Medicine ER -