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Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women.

Abstract

There is few data on the association between dietary fiber intake and estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk. We evaluated the association between dietary fiber and ER/PR-defined breast cancer risk stratified by postmenopausal hormone use, alcohol intake, and family history of breast cancer in the population-based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Fiber intake was measured by food-frequency questionnaire collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratio derived from Cox proportional hazard regression models. During an average of 8.3-year follow-up, 1,188 breast cancer cases with known ER/PR status were diagnosed. When comparing the highest to the lowest quintile, we observed non-significant inverse associations between total fiber intake and the risk of all tumor subtypes; the multivariate-adjusted RRs were 0.85 (95% CI: 0.69-1.05) for overall, 0.85 (0.64-1.13) for ER+PR+, 0.83 (0.52-1.31) for ER+PR- and 0.94 (0.49-1.80) for ER-PR-. For specific fiber, we observed statistically significant risk reductions for overall (34%) and for ER+PR+ (38%) for the highest versus lowest quintile of fruit fiber, and non-significant inverse associations for other subtypes of cancer and types of fiber. Among ever-users of postmenopausal hormone (PMH), total fiber intake and especially cereal fiber were statistically significantly associated with approximately 50% reduced risk for overall and ER+PR+ tumors when comparing the highest to the lowest quartile, but no association was observed among PMH never users. Our results suggest that dietary fiber intake from fruit and cereal may play a role in reducing breast cancer risk.

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  • Authors+Show Affiliations

    ,

    The National Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.

    , , , ,

    Source

    International journal of cancer 122:2 2008 Jan 15 pg 403-12

    MeSH

    Aged
    Breast Neoplasms
    Cohort Studies
    Diet
    Dietary Fiber
    Female
    Humans
    Middle Aged
    Multivariate Analysis
    Neoplasms
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17764112

    Citation

    Suzuki, Reiko, et al. "Dietary Fiber Intake and Risk of Postmenopausal Breast Cancer Defined By Estrogen and Progesterone Receptor Status--a Prospective Cohort Study Among Swedish Women." International Journal of Cancer, vol. 122, no. 2, 2008, pp. 403-12.
    Suzuki R, Rylander-Rudqvist T, Ye W, et al. Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women. Int J Cancer. 2008;122(2):403-12.
    Suzuki, R., Rylander-Rudqvist, T., Ye, W., Saji, S., Adlercreutz, H., & Wolk, A. (2008). Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women. International Journal of Cancer, 122(2), pp. 403-12.
    Suzuki R, et al. Dietary Fiber Intake and Risk of Postmenopausal Breast Cancer Defined By Estrogen and Progesterone Receptor Status--a Prospective Cohort Study Among Swedish Women. Int J Cancer. 2008 Jan 15;122(2):403-12. PubMed PMID: 17764112.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women. AU - Suzuki,Reiko, AU - Rylander-Rudqvist,Tove, AU - Ye,Weimin, AU - Saji,Shigehira, AU - Adlercreutz,Herman, AU - Wolk,Alicja, PY - 2007/9/4/pubmed PY - 2008/1/9/medline PY - 2007/9/4/entrez SP - 403 EP - 12 JF - International journal of cancer JO - Int. J. Cancer VL - 122 IS - 2 N2 - There is few data on the association between dietary fiber intake and estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk. We evaluated the association between dietary fiber and ER/PR-defined breast cancer risk stratified by postmenopausal hormone use, alcohol intake, and family history of breast cancer in the population-based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Fiber intake was measured by food-frequency questionnaire collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratio derived from Cox proportional hazard regression models. During an average of 8.3-year follow-up, 1,188 breast cancer cases with known ER/PR status were diagnosed. When comparing the highest to the lowest quintile, we observed non-significant inverse associations between total fiber intake and the risk of all tumor subtypes; the multivariate-adjusted RRs were 0.85 (95% CI: 0.69-1.05) for overall, 0.85 (0.64-1.13) for ER+PR+, 0.83 (0.52-1.31) for ER+PR- and 0.94 (0.49-1.80) for ER-PR-. For specific fiber, we observed statistically significant risk reductions for overall (34%) and for ER+PR+ (38%) for the highest versus lowest quintile of fruit fiber, and non-significant inverse associations for other subtypes of cancer and types of fiber. Among ever-users of postmenopausal hormone (PMH), total fiber intake and especially cereal fiber were statistically significantly associated with approximately 50% reduced risk for overall and ER+PR+ tumors when comparing the highest to the lowest quartile, but no association was observed among PMH never users. Our results suggest that dietary fiber intake from fruit and cereal may play a role in reducing breast cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/17764112/Dietary_fiber_intake_and_risk_of_postmenopausal_breast_cancer_defined_by_estrogen_and_progesterone_receptor_status__a_prospective_cohort_study_among_Swedish_women_ L2 - https://doi.org/10.1002/ijc.23060 DB - PRIME DP - Unbound Medicine ER -